ASPIRIN 75

ASPIRIN 75
30 May

ASPIRIN 75

Anticoagulant And Antithrombotic Agents

- ASPIRIN  is a salicylate NSAIDs, It’ s a well known analgesic,
  anti-inflammatory and antipyretic agent. It acts as inhibitor of the 
  enzyme cyclo-oxygenase, which results in the direct inhibition of 
  the biosynthesis, from arachidenic acid, of prostaglandin in  
  addition to thromboxanes leading to inhibits platelet aggregation 
- AASPIRIN  is formulated as enteric coated tablets hence the 
  absorption occur in the intestine to minimizes the possible local   
  gastric irritation.  
- ASPIRIN  is absorbed rapidly from G.I.T. It is 80 - 90%bound to 
  plasma proteins.
- ASPIRIN is widely and rapidly distributed in the body, appears 
  in breast milk and crosses the placenta.   
- ASPIRIN  is rapidly converted to salicylate but during the first
  20 minutes after absorption, ASPIRIN is the predominant form 
  of the drug in the plasma .
- ASPIRIN  is mainly eliminated by hepatic metabolism as 
  metabolites.its also excreted unchanged in the urine.

Indecation

 ASPIRIN  is used for inhibition of platelet aggregation in 
 patients at risk of the following cases:-  
- Acute myocardial infarction and  reinfarction prophylaxis. 
- Stable and unstable angina pectoris. 
- After vascular surgery or interventions(e.g. PTCA,CABG). 
- For the prevention of transient ischaemic attacks (TIA) and  
  cerebral infarction after the onset of precursor stages. 
- To prevent thrombosis of the coronary blood vessels in patients
  with multiple risk factors.
- For long –term prophylaxis of migraine . 
- Patients with deep vein thrombosis or a trial fibrillation.

Dosage & Administration

* ASPIRIN  tablets should be swallowed with plenty of  liquid. 
* ASPIRIN  is used for adults only as follows:-
-In unstable angina pectoris, In reinfarction prophylaxis and after
 arterial surgery or interventions:1 - 4 tablets daily. 
-In acute myocardial infarction:1- 2 ½ tablets daily. The first tablet
 should be chewed. 
-For the prevention of transient ischaemic attacks and cerebral 
 infraction:1 -4 tablets daily.  
-For the prevention of thrombosis of the coronary blood vessels
 and for prophylaxis of migraine:1 -2 ½ tablets daily.    
-Following arterial vascular surgery or intervention(e.g. after
 ACVB, in PTCA):1- 4 tablets daily.
- Or as directed by physician.

- Each Enteric Coated Tablet  of  ASPIRIN 75 contains: 
      Aspirin       75 mg
- Each Enteric Coated Tablet  of ASPIRIN 100 contains: 
     Aspirin        100 mg

ASPIRIN  is contra-indicated in the following cases:-
-Known hypersensitivity to acetylsalicylic acid and other NSAIDs.
-Stomach and duodenal ulcer.
-Pathologically increased tendency to bleed (eg hemophilia).
 

-Do not take ASPIRIN    concomitantly with the following drugs
 unless directed by the physician:-Anti coagulants (coumarin 
 derivatives and heparin) , sulfonylureas ,methotrexate, digoxin, 
 barbiturates and lithium ,sulfonamides and its combinations, 
 valproic acid ,aldosterone antagonists and loop diuretics, 
 antihypertensives, uricosurics and phenytoin. 
-ASPIRIN  may increase the risk of gastrointestinal bleeding when
 taken simultaneously with corticosteroides or alcohol.
-ASPIRIN  or other NSAIDs  should be avoided for 8 to12 days
 after mifepristone use.
-Concomitant use of calcium channel blockers increase the antiplatlet 
 effect of ASPIRIN 

-ASPIRIN  must not taken in last three months of pregnancy
 because of the increased risk of complication for mother and infant
 at birth. during the first and second trimester , ASPIRIN  should
 not be taken without doctor is consulted.  
-When longer- term use or higher doses more then (3 g/day) have
 been prescribed , early weaning should be considered discontinue 
 nursing.
 

ASPIRIN  is generally safe and well-tolerated. possible side
 effects may still occur include the following:-  
- GIT complaint such as stomach pain. occasionally nausea,
  vomiting and dyspepsia - Allergic reactions: such as skin rash or itching.
- Central nervous system disturbances: such as (headache, dizziness,
  tinnitus, visual disturbances and drowsiness),iron deficiency 
  anaemia (Iron deficiency) may occur with prolonged or chronic use.

 ASPIRIN   is should not be given to children and teenagers for 
 chicken pox or flu symptoms because the possibility of Reye’s
 syndrome (Rare but serious illness).
-ASPIRIN  should be used with caution in patients with ,asthma 
 and other allergic disorders, in dehydrated patients ,in presence of 
 uncontrolled hypertension ,in patients with glucose-6-phosphate 
 dehydrogenase deficiency.
-Caution  is necessary when renal or hepatic function is impaired
  and  ASPIRIN  should be avoided in severe renal or hepatic impairment.
-Prolonged use of ASPIRIN   should be avoided in the elderly
 because the risk of gastrointestinal bleeding and should be avoided 
 in patients with gout disease. 

- ASPIRIN    75 : Blisters of 10 tablets, pack of two blisters.
- ASPIRIN  100 : Blisters of 10 tablets, pack of two blisters.
 

- Store in a dry place  at room temperature below 25oC.   
- Protect from moisture and  light.