Azol 200

Azol 200
17 May

Azol 200

Anthelmintic

-Albendazole is benzimidazole Carbamate anthelmintic, it’s activity is 
 considered to be dependent on the inhibition or destruction of cytoplasmic 
 microtubules in the worm’s intestinal or absorptive cells, thus inhibition of 
 glucose uptake and depletion of glycogen stores and cholinesterase 
 secretion are impaired, and ATP production decreases causing energy 
 depletion, immobilization following as do other inhibitory effects leading 
 to death of worm within several days.
- Albendazole is poorly absorbed from the gastro-intestinal tract ,but may   
 be enhanced by a fatty meal. But rapidly undergoes extensive first pass 
 metabolism. The principal metabolite Albendazole sulphoxide has 
 anthelmintic activity and a plasma half-life of about 8.5 hours. 
-Albendazole sulphoxide is widely distributed throughout the body  
 including into the bile, cerebrospinal fluid, liver & urine. It’s 
 approximately 70% bound to plasma protein. Albendazole sulphoxide is 
 eliminated in  the bile; only  a small amount appears to be excreted in the 
 urine not less than  1% of the dose recovered in the urine. 

Indecation

- AZOL®  is indicated for the treatment of single or mixed helminthes 
 infections by:
-Enterobius vermicularis    (Pin worm or thread worm)
-Trichuris trichiura    (Whip worm)
-Ascaris lumbricoides    (Large round worm)
-Ancylostoma duodenale    (Hook worm)
-Necator americanus    (Hook worm)
-Strongyloides stercoralis              (Small round worm)
 Taenia spp.                                (Tape worm)
- In the treatment of parenchymal neurocysticerosis.
- in cystic hydatid disease of the liver, lung and peritoneum.    
- Also AZOL® is used in the treatment of cestode infections :  
 cysticercosis & echinococcosis (hydatid disease) in relatively high doses.
 It may also be used in the treatment of capillariasis, gnathostomiasis, 
 tissue nematodes infections, cutaneous larva migrans, toxocariasis,
 trichinosis & in combination with other anthelmintics in the treatment of 
 the filarial nematode infection lymphatic filariasis, activity has been shown 
 against the liver fluke Giardia lamblia.   

Dosage & Administration

 The tablets may be chewed, swallowed or crushed and mixed with food.
- Usual dose for adult & children over 2 years of age: 400mg of AZOL® as 
 a single dose  in cases of Enterobius vermicularis, Trichuris trichiura, 
 Ascaris lumbricoides, Ancylostoma duodenale & Necator Americanus.
- In case of strongyloidiasis or Taeniasis: 400 mg of  AZOL®  should be 
 given for 3 consecutive days.
 If the patient is not cured on follow-up after three weeks, a second course
 of treatment is indicated. 
-In children under 2 years of age : a single dose of 200 mg is effective in 
 common helminth infections.
-In the treatment of echinococcosis (hydatid disease)&Neurocysticercosis as: 
*In case of patient weight is less than 60kg, the dose should be15 mg/kg/day 
 given in divided dose b.i.d. with meals (maximum total daily dose 800 mg) .
*In case of patient’s weight is 60 kg or greater: 400 mg b.i.d. with 
 meals for 28 days .
*for cystic echinococcosis (hydatid disease): treatment is 28 days course may 
 be repeated after 14 days without treatment to a total of 3 treatment cycles.
 for alveolar echinococcosis : treatment is 28 days course may be repeated  
 after 14 days without treatment may need to continue for months or years .
*for Neurocysticercosis the duration of treatment is 8-30 days.
- Giardiasis: 400mg daily for 5 days. 
- Or as directed by the physician.
 

- Each Film coated tablet of AZOL® 400 contains:
  Albendazole      400 mg (USP)
-Each Film coated tablet of AZOL® 200 contains:
  Albendazole     200 mg (USP).
- Each 5 ml of AZOL® suspension contains:
  Albendazole     100 mg (USP).

 AZOL®  is contraindicated in the following cases:  
- patients with a known hypersensitivity to benzimidazole class .

- Concomitant administration of Dexamethasone or Praziquantel with AZOL® leads to increased Albendazole sulphoxide plasma concentration. 
-Concentrations of  Albendazole sulphoxide in bile & hydatid cystic fluid 
 were increased by administration of AZOL® with Cimetidine, which 
 may increase its effectiveness in the treatment of echinococcosis. 

- AZOL® should not be given for pregnant women or who are thought to be 
 pregnant. patients should not become pregnant for at least one month 
 following cessation of AZOL® therapy. 
-If pregnancy occurs while taking AZOL®, the patient shuld be discontinued  
 it immediately, and should apprised of the potential hazard to the fetus. 
- AZOL® should not given for lactating mothers. 
- AZOL® should be administrated within 7 days of the start of normal 
 menstruation.

 Generally AZOL® is well tolerated but there are some adverse reactions 
 such as:
- Transient abdominal pain, diarrhoea, headache, dizziness, loss of hair, fever, 
 fatigue, blood disorder including leucopenia and allergic reactions have been 
 reported.  
 

 Blood counts & liver function should be monitored in case of patients 
 receiving high doses of AZOL®  such as those  with echinococcosis at the 
 start of each treatment cycle of hydatid disease and every 2 weeks during 
 therapy.   

 AZOL® 400 Tablet:  blister of one tablet, Pack of one blister. 
 AZOL® 200 Tablet:  blister of 2 tablets, Pack of one blister.
 AZOL® 100 Oral suspension: bottle of 20 ml . 

- Store in a dry place below 30°C.
- Protect  from direct sunlight.