Diclo-k
- Diclofenac Potassium, a phenylacetic acid derivative, is a non-steroidal
compound with pronounced antirheumatic, anti-inflammatory, analgesic
and antipyretic properties.
- It inhibits prostaglandin biosynthesis which plays a major role in
causing inflammation, pain and fever. Medication with Diclofenac
Potassium can relieve the symptoms of inflammation, but can not cure
the cause.
- In rheumatic diseases, Diclofenac Potassium elicits a clinical response
characterized by marked relief from signs and symptoms such as pain at
rest, pain on movement, morning stiffness, and swelling of the joints, as
well as by an improvement in function.
- Diclofenac Potassium is almost completely absorbed. Food has no
clinical relevant influence on the absorption and bioavailability of
Diclofenac Potassium.
- No accumulation occurs provided the recommended dosage intervals
are observed even in patients suffering from renal impairment.
- 99.7% of Diclofenac Potassium is bound to serum proteins. It enters
the synovial fluid, and reaches higher levels in the synovial fluid than in
the plasma and remain higher for up to 12 hours.
- Diclofenac Potassium is subject to first-pass metabolism and then
excreted mainly in the urine (about 65%) but also in the bile (about
35%).