Diclof S.R 100
- Diclofenac sodium, a phenylacetic acid derivative, is a non-steroidal compound with pronounced antirheumatic, anti-inflammatory, analgesic and antipyretic properties.
- It inhibits prostaglandin biosynthesis which plays a major role in causing inflammation, pain and fever. Medication with Diclofenac sodium can relieve the symptoms of inflammation, but can not cure the cause. In rheumatic diseases, Diclofenac sodium elicits a clinical response characterized by marked relief from signs and symptoms such as pain at rest, pain on movement, morning stiffness, and swelling of the joints, as well as by an improvement in function.
- Diclofenac is almost completely absorbed. Food has no clinical relevant influence on the absorption and bioavailability of Diclofenac.
- No accumulation occurs provided the recommended dosage intervals are observed even in patients suffering from renal impairment. 99.7% of Diclofenac is bound to serum proteins. It enters the synovial fluid, and reaches higher levels in the synovial fluid than in the plasma and remain higher for up to 12 hours.
- Diclofenac is subject to first-pass metabolism and then excreted mainly in the urine (about 65%) but also in the bile (about 35%).