Doxylin

Doxylin
17 May

Doxylin

Antibiotics & Antibacterial

  Doxycycline hyclate is a synthetically derived tetracycline 
  with bacteriostatic properties against broad spectrum of 
  bacteria sensitive to tetracycline and has some antiprotozoal 
  properties, It acts by inhibiting protein synthesis in these 
  organisms. 
- The special pharmacological profile of Doxycycline with 
  high absorption in the GIT, high penetration of tissues, and 
  long biological half-life (15 - 25 hour) make it possible to 
  maintain blood and tissue concentration for 24 hours after a 
  single dose. Doxycycline thus affords such clinical 
  advantages as single daily dosage for most patients. 
- Doxycycline absorption is not affected by food and bound 
  to plasma proteins by 80- 95% , Doxycycline is not 
  excreted in the urine to the same extent as are other  
  tetracyclines and it does not accumulate in blood of patients 
  with renal failure. It is thus the safest of the tetracyclines in 
  the treatment of renal and extra renal infections. 
- Doxycycline is excreted in faeces up to 90% as an inactive 
  conjugate or as a chelate, for this reason it has relatively 
  less effect on intestinal micro flora. 

Indecation

DOXYLIN® is indicated in the following infections caused 
  by susceptible organisms:
- Infections of respiratory tract: pneumonia, laryngitis, 
  sinusitis, bronchitis, tonsillitis and otitis.    
- Infections of urinary tract caused by Klebsella and E.coli. 
- Infections of gastrointestinal tract and the bile duct.
- Venereal infections as syphilis, gonorrhea,  
   lymphogranuloma.  
- Pelvic inflammatory disease in women. 
- Other infections: infections of skin and soft tissues, oral 
  and dental infections, severe acne, eye infections and 
  malta fever.
- As an adjunct in the treatment of malignant Plasmodium 
  Falciparum malaria

Dosage & Administration

Capsules should be swallowed with a plenty of fluid in the 
 sitting or standing position. 
 Adults:     
- 200 mg as a single dose in the first 24 hours followed by  
  100 mg/24 hours. 
  In severe infections: 200 mg daily. 
Children: (8-12 years):
- 4 mg/kg body weight during the first 24 hours, followed by 
  2 mg/kg body weight every 24 hours.
DOXYLIN® Should only be used for children below 8 years 
  of age on very strong indications.
- Or as directed by the physician.

- Each capsule of  DOXYLIN® 100  contains:
  Doxycycline 100 mg (as Doxycycline Hyclate BP) 

- Hypersensitivity to tetracyclines. 
- Children below the age of 8 years, owing to the risk of 
  discoloration of the permanent teeth.
- Severe liver malfunction. 

- Doxycycline absorption is less likely to be affected by milk 
  or food, although it is still affected by antacids containing 
  aluminium, calcium or magnesium and iron preparations, 
  thus antacids should be taken 2 hours before or after 
  DOXYLIN® administration. 
- Oral Doxycycline reportedly may potentiate  the effects of 
  oral anticoagulants. 
- Doxycycline decrease insulin demand.
- Doxycycline decrease the efficacy of oral contraceptive.
- Doxycycline may increase the toxic effects of ergot alkaloids 
  and methotrexate. 
- Concomitant use of penicillins and DOXYLIN® , must be 
  avoided. 
- Alcohol, barbiturates,c arbanazepine and phenytoin reduce 
  the time Doxycycline half life in blood.
- Concomitant use of DOXYLIN® and methoxyflurane in  
  anesthesia has reported to cause fatal renal dysfunction.  

 Not recommended.

- Gastrointestinal complaints such as nausea, loss of   
  appetite, vomiting and diarrhea. 
- Photosensitivity.

- Drug should be discontinued at the first sign of erythema or 
  super infection.
- Renal, hepatic and haematologic systems should be   
  evaluated periodically during prolonged therapy. 

- DOXYLIN®Capsule 100 mg (Blister of 10 capsules, Pack of 
  one blister.)
- Hospital packs of different sizes.

- Store in a dry place  at a temperature below 25°C. 
- Protect from light.