LAVIA

LAVIA
20 May

LAVIA

Erectile Dysfunction Drugs

-Erections are usually controlled by a balance of two body chemicals.The
 first brings on erections; the second takes erections away.If the two   
  chemicals are out of balance, you can lose an erection before it starts.
- Vardenafil works by reducing the action of second chemical (PDE-5).  
 Vardenafil allows an erection to last long enough for you to satisfactorily 
 complete sexual activity. It is taken about 25 to 60 minutes before sexual
 activity and it will only work when you are sexually stimulated.
-Vardenafil is rapidly absorbed after an oral dose, with a bioavlability of
 about 15%, peak plasma concentration are attained with 30 to 120
 minutes. 
-The rate of absorption is reduced when Vardenafil is given with a high-fat
 meal.
-Vardenafil is widely distributed into tissues and is about 95% bound to 
 plasma proteins.
-Vardenafil is metabolised in the liver primarily by cytochrome P450 
 isoenzymes CYP3A4  as well as CYP3A5 and CYP2C isoform.
-The mean half-life of Vardenafil is about 4 -5 hours and the mean  
 clearance of Vardenafil may be reduced in the elderly and in patients with 
 hepatic or sever renal impairment.
-Vardenafil is excreted mainly in the faeces (91- 95 %) and to a lesser 
 extent in the urine (2- 6 %).

Indecation

 -Lavia® is indicated for Treatment of erectile dysfunction.
 -Lavia® is for men of 18 years and over.

Dosage & Administration

-Your doctor will suggested a suitable dose for you. Tell the doctor if you
 think Lavia® is too strong or too weak, may suggest a different dose,
 depending on how well it works for you.
-Take Lavia®  tablet about 25 to 60 minutes before sexual activity. With
 sexual stimulation you may achieve an erection anywhere from 25 minutes
 up to four or five hours after taking Lavia® tablet with a glass of water.
-You can take Lavia® with or without food but preferably not after heavy
 or high fat meal.
-Don’t use Lavia® more than once daily.

* Each film-coated tablet of  Lavia® contains:
   Vardenafil  (as hydrochloride trihydrate) 10 mg

- Lavia® is contraindicated in
- Hypersensitivity to Vardenafil include a rash, itching, swollen face or lips
 and shortness of breath.
- Any one taking nitrates such as glycerol trinitrate or nitric oxide donors, 
 such as amyl nitrite. Taking these drugs with Lavia®  could seriously affect
 on blood pressure.
- In patients with severe heart or liver problem.
- In patients with kidney dialysis.
- In case had a stroke or heart attack.
- In patients with low blood pressure.
- If the patient's family have a history of degenerative eye disease (such as
 retinitis pigmentosa).

-Vardenafil will usually be fine with most medicine. But some may cause
 problems, especiaslly these:-
- Nitrates, medicines for angina, nitric oxide donors, such as amyl nitrite.
 Taking these medicines with Vardenafil  could seriously affect your blood 
 pressure.
- Medication for treatment of arrhythmias such as Quinidine, Procainamide, 
 Amiodarone or Sotalol.
- Ritonavir or indinavir medicines for HIV.
- Ketoconazole or Itraconazole, anti-fungal medicines.
- Erythromycin ,an antibiotic.
- Alpha-blockers, a type of medicine used to treat high blood pressure and 
 benign prostatic hyperplasia.
- Don’t drink grapefruit juice it can interfere with the usual affect of the
 medicine.
- Alcoholic drink can make erection difficulties worse. 

- Lavia® is not indicated for use in women. 
 

- Most of the effect are mild to moderate.
-Very common side effects are headache and flushing.
- Common side effects are indigestion, feeling sick(nausea), dizziness and
 blocked or runny nose.
- Uncommon side effects are sensitivity of the skin to sunlight, high or low
 blood pressure, fainting, muscle stiffness or pain, back pain, effects on 
 vision, increase pressure in the eye (glucoma), bloodshot or watery eyes,
 rash, prolonged or painful erections, sleepness, effect in results of blood
 tests to check liver function, increase in blood of a muscle enzyme
 (creatine kinase), breathlessness, severe allergic reaction,                                                       
 effects on the heart (such as angina), fast heart beat or pounding heart, 
 nose bleeds and facial swelling.
- If any of these affects you badly, or dose not go away as you carry on
  taking Lavia® tell your doctor. 

Over dose: 
 Men who take too much Lavia®  may experience more side effects or may
 get severe back pain. If you take more Lavia®  than you should, tell your 
 doctor. 

 Contact with the physician in the following :
- Patients with heart trouble and cardiac arrhythmia or any congenital cardiac
 disease affecting your electrocardiogram.   
- Patients with physical condition affecting the shape of the penis. This
 includes conditions called angulations, peyronies disease and cavernosal
 fibrosis.
- Patients with an illness that can cause erections which won’t go away
 (priapism). These include sickle cell disease, multiple myeloma and
 leukaemia.
- Patients with stomach ulcers (peptic ulcer).
- Patients with bleeding disorder (such as hemophilia).
- In case use any other treatment for erection difficulties.
- Lavia® might make some people feel dizzy or effect their vision don’t  
 drive or operate any tools or machines.

- Blister of one tablet , pack of  four blisters. 
 

- Store in a dry place at a temperature below 25oC.