MODECEF 250

MODECEF 250
26 May

MODECEF 250

Antibiotics & Antibacterial

Cephradine is a semisynthetic cephalosporin antibiotic. It is rapidly 
 absorbed following oral administration in the fasting state. 
 The presence of food in the gastrointestinal tract delays the 
 absorption but does not affect the total amount of cephradine 
 absorbed. 
 Cephradine is a broad spectrum bactericidal antibiotic active 
 against both Gram-positive and Gram-negative bacteria including: 
 β-hemolytic Streptococci, Staphylococci,including  penicillinase 
 producing strains, Streptococci pneumonia, Escherichia coli, 
 Proteus mirabilis, Klebsiella species and Hemophilus influenza. 
 Cephradine is not active against most strains of Enterobacter 
 species, Enterococci,P.morganii,P.vulgaris. It has no activity against 
 Pseudomonas and Herellea species.

Indecation

MODECEF® is indicated in the following infections caused by 
 susceptible organisms:
- Infections of respiratory tract: pneumonia, pharyngitis and 
 tonsillitis. 
- Urinary tract infections including prostatitis 
- Other infections: otitis media, skin and skin structure infections. 

Dosage & Administration

Adults:     
- For respiratory tract infections (other than lobar pneumonia), skin
 and skin structure infections:  the usual dose is 250 mg every 6 
 hours or 500 mg every 12 hours.
- For lobar pneumonia: the usual dose is 500 mg every 6 hours or 1 g 
 every  12 hours.
- For uncomplicated urinary tract infections: the usual dose is 500 mg 
 every  12 hours.
- In more serious urinary tract infections including prostatitis 500  
 mg every 6 hours or 1 gm every 12 hours may be administered.
 -Larger doses (up to 1 g every 6 hours) may be given for severe
 or chronic infections.
Children: 
- Children over 9 months of age, 25-50 mg / kg/day administered in equally 
 divided doses every 6 or  12 hours. 
- For otitis media due to H . influenza 75-100 mg / kg /day administered in  
 equally divided doses every 6 or 12 hours but should not exceed 4g per day.
- Larger doses (up to 1g every 6 hours) may be given for severe or 
 chronic infections. 
- Or as directed by the physician

- Each capsule of MODECEF® 500 contains:
 Cephradine 500 mg (as Cephradine Monohydrate USP)
-  Each capsule of MODECEF® 250 contains: 
 Cephradine  250 mg (as Cephradine Monohydrate USP)
- Each  5ml of MODECEF® 250 for oral suspension  contains: 
 Cephradine 250 mg (as Cephradine Monohydrate USP)
- Each  5ml of MODECEF® 125 for oral suspension  contains: 
Cephradine 125 mg (as Cephradine Monohydrate USP)

MODECEF®is contraindicated in patients with known 
 hypersensitivity to any cephalosporin antibiotic. 

- (Amino glycosides, colisten, polymyxins, vancomycin) when 
 administered concurrently with cephalosporin may increase the 
 possibility of nephrotoxicity. 
- Potent loop diuretics such as (furosemide and ethacrynic acid)  
 enhanced possibility for renal toxicity. 
- Probenecid increase and prolong blood levels of cephalosporin, 
 resulting in increased risk of nephrotoxicity

 This drug should be used only if clearly needed.

As with other cephalosporin adverse reactions are limited essentially 
 to gastrointestinal disturbances and on occasion, to hypersensitivity 
 phenomena. 

- No  adequate information is available on the efficacy of b.i.d. 
 regimens of  MODECEF®  in  children under nine months.
- MODECEF®  used with caution in patients of markedly impaired 
 renal function or in patient with known or suspected renal 
 impairment. 
- A false  positive reaction for glucose  in the urine may occur with 
 Bendict’s solution, Fehling’s solution  or with Clinitest®  tablet but 
 not with enzyme based test such as Clinistix  and  Tes –Tape.  
- A false positive direct  coombs test has been reported after treatment 
 with cephalosporin.

 Capsule 250 mg or 500 mg 
 ( Blisters of 10 capsules, Pack of one blister.)
 Hospital packs of different sizes.
 For oral suspension  (Bottle of 100 ml after reconstitution.)

- Store in a dry place at  a temperature below 25°C.