PARADOL 10X10

PARADOL 10X10

- Paracetamol is a para-aminophenol derivative, which is a non-opioid,  
  nonsalicylate. It has analgesic, antipyretic properties and weak 
  anti-inflammatory activity. 
- Paracetamol produces central and peripheral analgesia by elevation of 
  the pain threshold and inhibition of prostaglandin biosynthesis and 
  antipyretic action through the effect on the hypothalamic 
  heat-regulating center, resulting in peripheral vasodilatation; increased 
  blood flow through the skin, sweating and heat loss.  
- Paracetamol is readily absorbed from the gastro-intestinal tract with 
  peak plasma concentrations occurring about 10 to 60 minutes after oral 
  administration. 
- Paracetamol is distributed into most body tissues. It crosses the 
   placenta and is present in breast milk. 
- Paracetamol is metabolised predominantly in the liver and excreted in 
  the urine mainly as the glucuronide and sulphate conjugates. Less than 
  5% is excreted as unchanged Paracetamol. 
-The elemination half-life ranges from 1 to 3 hours.

- Each tablet of  Paradol®  contains: 
   Paracetamol                   500 mg 
• Each 5 ml of  Paradol® 250 Oral Suspension contains:
  Paracetamol                   250 mg
• Each 5 ml of  Paradol® 160 Oral Suspension contains: 
  Paracetamol                    160 mg
• Each 1 ml (25 drops) of  Paradol®  Infant Drops contains:
  Paracetamol                   100 mg
• Each suppository of  Paradol® 250 Suppositories contains:
  Paracetamol                  250 mg
• Each suppository of Paradol® 125 Suppositories contains:
  Paracetamol                 125 mg

  Paradol® is contraindicated in the following cases: 
- Patients with hypersensitivity to paracetamol. 
- Patients suffering  from chronic renal and/or hepatic diseases. 

- Paradol® absorption may be accelerated by drugs such as   
  metoclopramide . 
- Paradol® absorption may be reduced if given within one hour of 
  colestyramine use.
- Paradol® excretion may be affected and plasma concentration altered 
  when administered with probenecid, pretreatment with probenecid can 
  decrease paracetamol clearance and increase its plasma half life.

  Although there is epidemiological evidence of the safety of Paradol®in 
  pregnancy and lactation, medical advice should be sought before using 
  this product. 

  Paradol® has rare side effects at recommended dose, which include:-
- Skin rash, other hypersensitivity reactions and hematological reactions 
  occur occasionally. 
- Hepatotoxicity after large doses or prolonged treatment.  

 Paradol® should be given with care to patients with impaired kidney or liver functions and in patients taking other drugs which may affect the liver 

  Tablets: 
- Blisters of 10, 12 tablets, Packs of 2 blisters.
- Blisters of 10, 12 tablets, Packs of 10 blisters.
- Strips of 10 tablets, Packs of 50 strips.
- Hospital packs of different size.
- Suspension: Bottles of 60 ml ,100ml . 
- Drops: Bottles of 15 ml with insert dropper. 
- Suppositories: Packs of 10 suppositories.

 Store below 25 °C in dry place away from light.