PARADOL Strips
- Paracetamol is a para-aminophenol derivative, which is a non-opioid,
nonsalicylate. It has analgesic, antipyretic properties and weak
anti-inflammatory activity.
- Paracetamol produces central and peripheral analgesia by elevation of
the pain threshold and inhibition of prostaglandin biosynthesis and
antipyretic action through the effect on the hypothalamic
heat-regulating center, resulting in peripheral vasodilatation; increased
blood flow through the skin, sweating and heat loss.
- Paracetamol is readily absorbed from the gastro-intestinal tract with
peak plasma concentrations occurring about 10 to 60 minutes after oral
administration.
- Paracetamol is distributed into most body tissues. It crosses the
placenta and is present in breast milk.
- Paracetamol is metabolised predominantly in the liver and excreted in
the urine mainly as the glucuronide and sulphate conjugates. Less than
5% is excreted as unchanged Paracetamol.
-The elemination half-life ranges from 1 to 3 hours.