URIKIN

URIKIN
29 May

URIKIN

Urinary Tract Therapy

URIKIN® is  a multifunctional formulation 
 combining three active ingredients with  
 multiple complementary activities on  the 
 urinary  tract. Hexamine and Piperazine citrate 
 are rapidly absorbed from the gastrointestinal 
 tract and a great part of them reaches the urine 
 unchanged.
 Hexamine is rapidly and almost completely 
 eliminated in the urine, where it is slowly 
 hydrolysed in acidic medium  to ammonia and 
 formaldehyde. The half-life is approx. four 
 hours. 
 The peak concentration of formaldehyde is up to 
 2 hours after administration. The produced  
 formaldehyde has antiseptic effect  to which  
 uropathogens are susceptible and do not develop 
 resistance on long  term  treatment, those benefit 
 to use for long term treatment.
 Piperazine citrate which adds to the benefit of  
 URIKIN® by  increasing uric acid excretion and 
 dissolving urate crystals, and through its acidic 
 nature, it potentiates the antibacterial effect of 
 Hexamine. 
 Khellin is the third ingredient of plant origin, has 
 a direct powerful and long lasting antispasmodic 
 action on the smooth muscles of the urinary 
 tract.
 These properties make URIKIN® Effervescent 
 Granules a drug of choice with multiple actions 
 and wide  range of safety when used for long 
 term.

Indecation

- Chronic urinary tract infections including 
 pyelitis, pyelonephritis, cystitis and infections 
 accompanying neurogenic  bladder.
-Prevention of  re-infection of sterile urine in 
 patients with residual urine accompanying some 
 neurological diseases and with prolonged 
 bladder catheterization.
-Spasms of the urinary tract and relief of 
 discomfort caused by hypermotility resulting 
 from inflammation as in cystitis, prostatitis, 
 urethritis and urethrocystitis.
-In prevention of urinay tract lithiasis(uratestones.)

Dosage & Administration

 Unless otherwise prescribed by  the physician the 
 contents of one or two sachets to be dissolved  in 
 half a glass of water and taken three times daily.

- Each sachet  contains: 
 Hexamine      500 mg
 Piperazine citrate    190 mg
 Khellin        1.83 mg

- Patients with hepatic or renal insufficiency. 
- Renal or heart  failure and severe dehydration.
- Metabolic acidosis.
- Neurological disturbances and epilepsy.
- Hypertension & odema.
 

 Concomitant use of Hexamine and Sulphonamides 
 may increase the risk of crystalluria.
 The concomitant use of Hexamine with urine 
 alkalinizers including some antacid, potassium-
 citrate, and diuretics must be avoided because the 
 activation of Hexamine to formaldehyde may be  
 inhibited.
 

-It advised not to  be used during pregnancy, 
 especially in the first trimester unless the 
 treatment is essential.
-Use with  cautions with breast feeding, mother 
 should be breast feed after 8 hours of dosing.
 

 URIKIN® is well  tolerated but sometimes may  
 cause:
* GIT disturbances ( e.g. nausea and vomiting.)
* In rare case  hypersensitivity reactions (including 
 skin rash & bronchospasm.) 

 Overdose may rarely produce nervous complica 
 tions, especially in patients suffering from 
 disturbance in the renal functions.

 Box containing 6 or 12 sachets.
 

 Keep in a dry place away from moisture and light 
 at a temperature not more than  25oC  .