Abilifin 30
- Aripiprazole is an antiscychotic drug which belongs to atypical antipsychotic
group.
- Abilifin® tablets are 87% bioavailable and reach peak plasma concentrationsin 3 to
5 hours. These tablets can be taken with or without food, but a high fat meal can
delay the time to max concentration by 3 hours and up to 12 hours for the active
metabolite.
- protein binding of Aripiprazole is >99%.
- The half life of aripiprazole is 75 hours while the half life of the active
metabolite is 94 hours. Elemination of aripiprazole is mainly through hepatic
metabolism involving two P450 isozymes, CYP2D6 and CYP3A4.
For populations that are poor CYP2D6 metabolizers, the half life of aripiprazole
is 146 hours and these patients should be treated with half the normal dose.