ATORVA PLUS 20/10
- Atorvastatin is a selective competitive inhibitor of HMG – COA reductase which is the rate - limiting
enzyme responsible for conversion of (HMG – COA) to Mevalonate, a precursor of sterols including
cholesterol.
- Atorvastatin is rapidly absorbed after oral administration , plasma concentrations(Cmax) occure
within 1-2 hours
- More than 98% of Atorvastatin is bond to plasma proteins.
- Atorvastatin undergoes an extensive metabolism to active ortho and para metabolites hydroxylated
which 70% of circulatory inhibitory activity of HMG -COA reductase is attributed to active
metabolites .
- Atorvastatin is eliminated primarily in bile following hepatic and / or extrahepatic metabolism.
- Mean plasma elimination half – life of Atorvastatin in humans is approximately 14 hours.
- The half life of inhibotry activity for HMG-COA reductase is approximately 20-30 hours due to the
contribution of active metabolites.
- Ezetimibe is a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of
cholesterol and related phytosterols.
- Ezetimibe is absorbed and extensively conjugated to pharmacologically Active phenolic glucoronide
(Ezetimibe glucoronide).
- Ezetimibe and Ezetimibe glucoronide are highly bound (90 %) to human plasma proteins.
- Ezetimibe is primary metabolized in small intestinal and liver via glucoronide conjugation with
subsequent billary and renal excretion.