- Folin-B6® contains two important
constituents in the treatment of Megaloplastic
anaemia, and chronic debilitating diseases.
-Folic acid is essencial for normal
erythropoiesis and is used in the management
of megaloblastic anaemia.
-Vitamin B6 is essencial for metabolism of
amino acids, lipids, and carbohydrates.
Vitamin B6 deficiency affects mainly
peripheral nerves and the hematopoietic
systems.
- Megaloblastic anaemia.
- Patients suffering from peripheral neuropathy
and associated nervous system involvement.
- Increased requirements of folic acid and
vitamin B6 , e.g. pregnancy, lactation,
thyrotoxicosis, liver or kidney diseases and
malignancy.
- Chronic debilitating diseases.
- Initial therapy: 1 to 3 tablets according to
case.
- Maintenance dose: ½ to one tablet.
Each film coated tablet of Folin-B6®
contains :-
- Folic acid 5 mg.
- Vitamin B 6 (pyridoxine) 50 mg
Hypersensitivity to any API (s) of the
preparation.
- Folate deficiency may be produced by:
antiepileptics, oral contraceptives, antitubercu
lous drugs, alcohol and folic acid antagonists
such as methotrexate, pyrimethamine,
triamterene, trimethoprime and sulfonamides,
so dose of Folin-B6® must be increased in this
case.
- Pyridoxine reduces the effects of levodopa and
altretamine. Also it decreases serum concentra
tions of phenobarbital and phenytion.
- Many drugs may increase the requirements of
pyridoxine, such drugs include hydralazine,
isoniazid, penicillinamine, and oral contracep
tives.
Folin-B6® can be used during pregnancy and
lactation.
Folin-B6® is generally well tolerated.
Gastrointestinal disturbances and hypersensitivity reactions have been reported rarely.
- Long- term of large doses of pyridoxine is
associated with the development of severe
peripheral neuropathies, the dose at which
those occur is controversial
-Blister of 10 tablets, pack of 3 blisters.
-Hospital packs with different sizes.
-Store in a dry place, at a temperature below
30 °C.
