IBOFEN 400

IBOFEN 400
27 May

IBOFEN 400

Analgesics, Antipyretics, Anti-Inflammatory drugs

-Ibuprofen is a propionic acid derivative and non steroidal
  anti-inflammatory drug (NSAIDs). It possesses potent  analgesic 
  and antipyretic properties. It inhibit prostaglandin synthesis by 
  decreasing the activity of the enzyme cyclo-oxygenase, 
  which results in decreased formation of prostaglandin precursors.
- Ibuprofen is well absorbed orally and is 90 to 99% bound to 
  plasma proteins and has a plasma half-life of about 2 hours.
-It rapidly excreted in the urine mainly as metabolites and their 
  conjugated.
-About 1% is excreted in urine as unchanged Ibuprofen and 
  about 14% as conjugated Ibuprofen.
-    It has fewer side-effects than other NSIDs.. 

Indecation

IBOFEN® is used in management of mild to moderate pain and
  inflammation in conditions such as: 
-    Musculoskeletal and joint disorder such as ankylosing spondylitis and  juvenile idiopathic arthritis;
-    Rheumatoid arthritis and peri-articular  disorder.
-    Pelvic inflammation and dysmenorrhoea.
-    Toothaches, oral surgical procedures and dental extraction.
-    Painful swelling or inflammation after injuries and operation.  
-    Periarticular disorders such as tenosynovitis and bursitis;
-     Soft-tissue disorders such as sprains and strains.
-     It is also used to reduce fever. 
-    Headache including migraine.
 

Dosage & Administration

-    Administer with or after food or milk to reduce the gastrointestinal effects.
 Adult :
-    The usually daily dose is 1200 to 1800 mg in divided doses. This can be increased to 2400 mg total daily dose 
  if necessary in conditions.
Children :    
-    Daily doses of IBOFEN®  oral suspension in terms of age:
6- 12 months: 2.5 ml 3 times daily.
1- 2 years: 2.5 ml 3 - 4times daily.
2 -7 years: 5 ml 3- 4 times daily.
7 years & over: 10 ml 3- 4 times daily.
-    Daily doses in terms of body weight (for children and infants weighing more than 7 kg).
 Juvenile Rheumatoid Arthritis: 30- 40 mg/kg daily in
  3 - 4 divided doses.
 Antipyretic, Analgesic: 20 -30 mg/kg daily in divided doses.
-    Or as directed by the physician.
 

-Each tablet of IBOFEN®  600 mg contains :
  Ibuprofen                                        600 mg
-Each tablet of IBOFEN®  400 mg contains :
  Ibuprofen                                        400 mg
-Each tablet of IBOFEN®  200 mg contains :
 Ibuprofen                                        200 mg
-Each capsules of IBOFEN®  300 (sustained release)  contains :
 Ibuprofen                                        300 mg
-Each 5 ml of IBOFEN®  oral suspension contains :
 Ibuprofen                              100 mg

   IBOFEN® is contraindicated in: 
-    Known hypersensitivity towards Ibuprofen, aspirin, or other NSIDs.
-    Unexplained blood formation disturbances.
-    Patients with active peptic ulcer, GI bleeding
-    Individual with syndrome of nasal polyps, asthma and bronchospastic reactivity to aspirin or other NSIDs.   
-    In coagulation defects. 

-    The simultaneous administration of IBOFEN® together digoxin, phenytoin, lithium or methotrexate they 
  increased the plasma level of these medications.
-    The simultaneous administration of IBOFEN® and glucocorticoids or other NSIDs increased the risk of side 
  effect in the G.I.T.
-    Concomitant administration of IBOFEN® with diuretics (Furosemide and thiazides) or ACE inhibitors   
  may reduce the effect of these medications.
-    Meclobemide enhances the effects of IBOFEN®.
-    There may also be an increased risk of hyperkalaemia with ACE inhibitors and potassium-sparing diuretics;
-    Enhancement of the effects of oral anticoagulants, 

IBOFEN® is well tolerated, with low incidence of side effects.
-    Gastrointestinal disturbances, peptic ulcer, severe gastric pain or vomiting.
-    Other side effects include: hypersensitivity reaction such as skin rashes, itching as well as asthma attacks.
-    Rarely, asymptomatic thrombocytopenia and gastrointestinal bleeding and ulceration have been reported.   
 

IBOFEN® should be used with caution in :
-    Patients with considerable dehydration.
-    Patients with significantly impaired renal function should be closely monitored and a reduction in dosage of 
  IBOFEN® should be anticipated to avoid drug accumulation.
-     IBOFEN® should be used with caution in persons with intrinsic coagulation defects and those on anticoagulant therapy. 
-    Like other NSIDs, IBOFEN® should be used with caution in patients with asthma or allergic disturbances.  
-    CNS adverse effects such as confusion, agitation & hallucination are generally seen in overdose situations. 
-    IBOFEN® is preferable to avoid in patients with current or previous GI ulceration or bleeding. 
 

- Tablet: Blister of 10 tablet, pack of two blister,5 and 10 blister.
- Capsule : Blister of 10 capsules, pack of 1 blister.
- Oral suspension : Bottle of 60 ml or 100 ml Oral Suspension.
- Hospital packs of different sizes.
 

Store at temperature not exceeding 25○C.