LANZOL 30
Lansoprazole belongs to a class of antisecretory
compounds,that do not exhibit anticholinergic or
histamin H2-receptor antagonist properties ,but that
suppress gastric acid secretion that acts by specific
inhibition of the H+/K+-ATPase enzyme system.
- Lansoprazole may be useful in patients failing on a
histamine H2-receptor antagonist (Cimetidine,
Ranitidine, Famotidine or Nizatidine).
- Absorption of lansoprazole begins only after the pellets
leave the stomach. Absorption is rapid, with peak plasma
concentrations achieved about 1.5 hours after a dose by
mouth; bioavailability is reported to be 80% or more even
with the first dose.
- lansoprazole is extensively metabolized in the liver and
excreted primarily in faces via bile,only about 15 to
30% of a dose is excreted in urine the plasma elimination
half-life is around 1.4 to 2 hours but the duration of action
is much longer .