Lefoxin 500mg-10tab.

Lefoxin 500mg-10tab.

Lefoxin 500mg-10tab.

Antibiotics & Antibacterial


  oral administration. 
  Levofloxacin is rapidlyl absorbed . The absolute bioavailability is approximately    
 100% . Food has little effect on the absorption of Levofloxacin . Levofloxacin is   
  approximately 30 - 40% bound to serum proteins. Steady state is achieved  within 3 
  days . 
- Levofloxacin penetration into  bone tissues, blister fluid, and lung tissue is good but 
  is poor into cerebra-spinal fluid . 
- Levofloxacin is metabolised to a very small extent, the two metabolites  account  
  for 5% of dose excreted in urine .
- Levofloxacin is eliminated relatively slowly from the plasma (t½ :6-8 h).
  Excretion is primarily by renal route( >85% of the administerated dose) . 
 

Indecation

 It has been used in the treatment of the following infections including: 
- Acute sinusitis. 
- Acute exacerbation of chronic bronchitis. 
- Community-Aquird pneumonia .
- Complicated urinary  tract infection including pyelonephritis .
- Skin and soft  tissue  infections, 
- Prostatitis.

Dosage & Administration


- Lefoxin® should be swallowed without crushing and with  sufficient amount of 
  liquid they may be divided at the score line to adapt the dosage. The dose maybe   
  taken during meals or between meals 
  The dosage depend on the type and severity of the infection and sensitivity of the 
  presumed causative phathogen.
- Acute sinusitis: Lefoxin®  500 once daily for 10 to 14 days .
- Acute exacerbation of chronic bronchitis : Lefoxin®  250- 500 mg once daily 
  for 7- 10 days .
- Community-Acquired pneumonia : Lefoxin® 500 once or twice daily for 7- 14  
  days .
- Complicated urinary  tract infection including pyelonephritis : Lefoxin®  250 
  once daily for 7 -10 days
- Skin and soft  tissue  infections: Lefoxin®  250  once daily or Lefoxin®  500   
  once or twice  daily for 7- 14 days.

- Prostatitis : Lefoxin® 500  once daily for 28 days.
- Dosage in adult patients with impaired renal function creatinine clearance ≤  
  (50ml/min)

** No dosage adjustment is required in patient with impaired liver function and 
 elderly patients.

* Each film-coated tablet of  Lefoxin® 500 contains: 
   Levofloxacin                500 mg
* Each film-coated tablet of  Lefoxin®  250 contains: 
   Levofloxacin         

- Lefoxin®  is contraindicated in patients of hypersensitivity to Levofloxacin or  
  other quinolone or to with a history of tendon disorders related to fluoroquinolone  
  administration .

- in patient with epilepsy   
- Children,or adolescent.
- During pregnancy and breast-feeding mothers .

-Fluoroquinolones are known to inhibit hepatic drug metabolism and may interfere 
 with the clearance of drugs metabolized by the liver such as theophylline.


  As with other quinolones, side effects are usually:
- Gastrointestinal disturbances including: nausea, anorexia, vomiting, diarrhoea, 
  abdominal pain and dyspepsia. 
- Nervous system: Headache, dizziness/vertigo, drowsiness and insomnia . 
- Skin and allergic reaction  : Rash, pruritis, urticaria , bronchospasm/ dyspnea , 
  odema  .
- Cardiovascular system : tachycardia , hypotension .
- Muscule and skeleton : arthragia , myalgia .


Overdose :-
- In case of over dose, contact immediately your physician . 
- Most important signs  of Levofloxacin overdose  are confusion, dizziness, 
  impairment of consciousness, convulsive seizures, gastrointestinal reactions such as 
  (nausea and mucosal erosions ) in the event of the overdose the patient should be 
  carefully observed( including ECG monitoring) and symptomatic treatment should 
  be implemented.
- In cases of acut oral overdose, gastric lavage should also be considerd and antacids 
  may be used for protection of gastric mucosa. Haemodialysis, including peritoneal 
  dialysis and CAPD, are not effective in removing Levofloxacin from the body.  
- According to toxicity studies in animals, confusion, dizziness, impairment of 
  consciousness, convulsive seizure , nausea and mucosal erosions.
- In the event of overdose contact immediately your physician and the patient  should 
  be carefully observed .

-Lefoxin® should be used with caution in patients with renal and hepatic 
 impairment, glucose-6-phosphate dehydrogenase deficiency.
-During treatment, patients should not expose themselves to sunlight, UV rays or 
 sunray lamp (due to photosensitivity reactions.) 
-Diarrhea, particularly if sever, persistent or bloody, during or after treatment, may 
 be symptomatic of pseudo-membranous colit due to clostridium difficile and must 
 be stopped immediately .
-Tendinitis, this undesirable effect may occur within 48 hours of starting of treatment 
 must be stopped immediately .
-Avoid driving or other activities requiring alertness. 
-As with other antibiotic, especially if prolonged ,may result in overgrowth of 
 non-susceptible organism. 
-Antiacid, aluminium, magnesium or iron  should not be taken within 2 hours 
 because of a possible reduce the absorption. 

Lefoxin® 500  Tablets (Blister of 5  Tablets, Pack of one blister)
 Lefoxin® 250  Tablets (Blister of 10 Tablets, Pack of one blister)

Store in a dry place at a temperature  not exceeding 30 ºC.