Moxalin 1000

Antibiotics & Antibacterial

Amoxicillin is well absorbed from the gastrointestinal tract
giving high concentration in the serum, tissues and urine. The
ingestion of food does not greatly reduce the absorption of
Amoxicillin.
Amoxicillin is a broad spectrum antibiotic effective against
both Gram-positive and Gram-negative organisms including:
α- and β-hemolytic streptococci, Pneumococci, non
penicillinase producing Staphylococci, Diphtheria, H.
influenzae, Salmonella, Shigellae, E. coli, some Proteus
strains, Brucellae, Gonococci and Meningococci.

Indecation

MOXALIN® is indicated in the following infections caused
by susceptible organisms:
- Infections of respiratory tract: pneumonia, bronchitis,
tonsillitis, pharyngitis, laryngitis and otitis media.
- Infections of genitourinary tract: cystitis, urethritis,
pyelonephritis and gonorrhea.
- Other infections: skin and soft tissue infections and typhoid
resistant to chloramphenicol.
- Prophylaxis of endocarditis, may be used for the prevention
of bacteraemia.
- With another drugs to treat stomach ulcers caused by
Helicobacter pylori infection.

Dosage & Administration

- Usual dosage range:
Adult: 250–500 mg every 8 hours. 1000 mg every 12 hours.
Children: 125–250mg every 8 hours.
- Typhoid and paratyphoid:
Adults: 4 g daily in divided doses for 14 –21 days.
Children: 100 mg/kg/day in divided doses for 14 –21 days.
- Uncomplicated urinary tract infection: A single dose 3g.
- Otitis media: 750mg twice daily for two days may be used
in children of 3–10 years.
- Lower respiratory tract infection 500 mg three times daily.
- MOXALIN®1gm twice dialy combination with
CLAROMIN® and OMEPRA® to treatment Helicobacter
pylori infection.
- Suggested dosages for renal impairment:
- Moderate renal impairment (creatinine clearance 10 –30
ml/min):
For adult and children over 40 kg: 500 mg twice daily
maximum, but for children under 40 kg :15 mg/kg twice
daily.
- Severe renal impairment (creatinie clearance <10 ml/min):
For adult and children over 40 kg : 500 mg/day maximum, but
for children under 40 kg : 15 mg/kg by mouth.

Composition

- Each film coated tablet of MOXALIN® 1000 contains:
Amoxicillin   1000 mg (as Amoxicillin Trihydrate USP)
- Each capsule of MOXALIN® 500 contains:
Amoxicillin   500 mg (as Amoxicillin Trihydrate USP)
- Each capsule of MOXALIN® 250 contains:
Amoxicillin   250 mg (as Amoxicillin Trihydrate USP)
- Each 5 ml of MOXALIN® 250 for oral susp. contains:
Amoxicillin   250 mg (as Amoxicillin Trihydrate USP)
- Each 5 ml of MOXALIN® 125 for oral susp. contains:
Amoxicillin   125 mg (as Amoxicillin Trihydrate USP)
- Each 1 ml of MOXALIN® for Infant Drops contains:
Amoxicillin   100 mg (as Amoxicillin Trihydrate USP)

Contraindecation

MOXALIN® should not be administered to patients who have
shown hypersensitivity to penicillins.

Pregnancy & Lactation

- MOXALIN® suitability in human pregnancy has been well
  documented in clinical studies.
- During lactation, trace quantities of MOXALIN® can be
  detected in breast milk, caution should be excercised when
  administerted to nursing woman.

Side Effects

Side effects, as with other penicillins, are usually of a mild and
transitory nature: may include diarrhea, indigestion or skin
rash.

Precaution

- The possibility of super-infections with mycotic or bacterial
pathogens should be kept in mind during therapy. If
super-infections occur, the drug should be discontinued and
appropriate therapy instituted.
- The possible occurrence of anaphylactic reactions should also
be borne in mind.
- There should be monitoring of plasma and urine levels for
patients with renal impairment.

Packing

- MOXALIN® 1000 mg film coated tablet:
Blister of 5 tablets, Pack of two blisters.
- MOXALIN® 500 mg or 250 mg Capsule:
Blister of 10 capsules, Pack of two blisters.
Blister of 10 capsules, Pack of 10 blisters.
Hospital packs of different sizes.
- For oral suspension:
Bottle of 100 ml after reconstitution.
- Infant Drops: Bottles of 10 ml after reconstitution.

Storage

- Store in a dry place at a temperature below 25 °C.