Omeprazole belongs to a new class of antisecretory
 compounds, that inhibits gastric acid secretion by irreversibly
 blocking the H+/K+ ATPase enzyme system, (the proton 
 pump) of the gastric parietal cell, so it blocks the final step of
 acid production. This effect is dose-related and leads to
 inhibition of both basal and stimulated acid secretion
 irrespective of the stimulus.
-OMEPRA®  capsules contain an enteric coated pellets
 formulation of Omeprazole (because Omeprazole is
 acid-labile), so that absorption of Omeprazole begins only
 after the pellets leave the stomach. Omeprazole is rapidly
 absorbed from the small intestine and its absorption is not 
 affected by food. Peak plasma levels of Omeprazole
 occurring within 0.5 to 3.5 hours. It is highly bound to plasma
 proteins (about 95%),extensively metabolized in the liver and
 rapidly eliminated as inactive metabolites mostly in the urine. 

Each capsule of OMEPRA®  20 contains: 
   Omeprazole   20 mg       (As enteric coated pellets)

Hypersensitivity to Omeprazole. 

  the metabolism of some other drugs metabolised by these 
  enzymes. It can prolong the elimination of Diazepam, 
  Phenytoin and Warfarin. 
- The decreased gastric acidity caused by Omeprazole may 
  affect the absorption of other drugs given concomitantly
  such as: Ketoconazole, Ampicillin esters and Iron salts. 
- Plasma concentrations of Omeprazole and Clarithromycin
  are increased during concomitant administration. 

OMEPRA®  should not be administered during pregnancy
  and lactation unless strictly indicated, and as directed by the
  physician .

OMEPRA® is well tolerated and adverse reactions have
  generally been mild and reversible. 
- The most frequent side effects are gastro-intestinal
  disturbances, in particular diarrhoea, skin rash, and 
- The rare side effects include arthralgia, myalgia, and blood

- OMEPRA®  is not recommended for patients with
  suspected gastric tumors as it might alleviate symptoms and
  delay diagnosis.  
- Dosage should be reduced in hepatic impairment. 

- Plastic jar of 14 capsules with a desiccant.
- Strip of 10 capsules, pack of 10 strips. 
- Hospital packs of different sizes.

Store in a dry place at a temperature below 30oC, protected from light and humidity.