Osen 500

Osen 500

- Phenoxymethylpenicillin, an antimicrobial acid, is a highly potent 
  antibacterial oral penicillin. It exerts its killing action on growing 
  and dividing bacteria by inhibiting bacterial cell-wall synthesis. 
  The spectrum of action is virtually identical to that of 
  benzylpenicillin. Phenoxymethylpenicillin has bactericidal action 
  against Gram-positive bacteria and may be less active against some 
  susceptible organisms particularly Gram-negative bacteria. It 
  covers group A,C, G,H,L, and M Streptococci, Streptococcus
   pneumonia, non-penicillinase-producing Staphylococci, 
   Neisseriae, Erysipelothrix rhusiopathiae, Bacillus anthracis and 
  spirochetal species as well as numerous anaerobic agents are
   also sensitive. 
- Phenoxymethylpenicillin potassium is not effected by gastric acid. 
  Absorption is usually rapid and the potassium salt is better 
  absorbed than the free acid. About 80% is reported to be protein 
- Phenoxymethylpenicillin is widely distributed at varying
  concentrations in body and fluids. It is metabolized in the liver.
- Most of the applied dose is eliminated along renal pathways in an 
  unchanged form. Biliary elimination of the active drug is confined
  to a minor fraction of the dose.

- Each film-coated  tablet of OSEN® 1000 contains: 
   Phenoxymethylpenicillin  as potassium      1.000.000 i.u
- Each film-coated  tablet of OSEN® 500 contains: 
   Phenoxymethylpenicillin  as  potassium    500.000 i.u
- Each 5ml of OSEN® 250 oral solution contains: 
   Phenoxymethylpenicillin  as potassium     400.000 i.u
- Each 5ml of OSEN® 125 oral solution contains: 
   Phenoxymethylpenicillin as potassium      200.000 i.u

- History of penicillin or cephalosporins hypersensitivity.
- Manifest gastrointestinal disturbance (diarrhea,vomiting).  

- OSEN® should not be combined with bacteriostatic antibiotics. 
- Competitive inhibition of OSEN® elimination should be 
   remembered, whenever NSAIDs (indomethacin, phenylbutazone 
   and salicylate in high doses) or probenecid are used comcomitantly.
- Ingestion of  OSEN® with meals reduces the absorption of the drug.

- There is no evidence suggesting that OSEN® has embryotoxic, 
   teratogenic or mutagenic effects. 
- OSEN® may be present in breast milk.

- OSEN® is usually well tolerated but may occasionally cause 
   transient nausea and diarrhoea. 
- The most common adverse effects are hypersensitivity reactions 
  especially skin rash.   

- Patients known to be hypersensitive to penicillins should be given an 
  antibacterial of another class. 
- Dosage may need to be modified in severe renal impairment. 
- During long-term treatment attention should be paid to the potential   
  overgrowth of resistant micro-organisms and fungi. 
- Particular caution should be exercised in patients with an allergic 
  diathesisor with bronchial asthma.

- OSEN® 1000 tablet :(Blister of 10 tablets , pack of 2 blisters)
- OSEN® 500 tablet :(Blister of 10 tablets , pack of 2 blisters)
- OSEN® 250 Oral solutions (bottle of 100 ml after reconstitution)
- OSEN® 125 Oral solutions (bottle of 100 ml after reconstitution)

- Store  in dry place, at a temperature below 250C
- After reconstitution store in a refrigerator and use within one week.