pantrol 40

pantrol 40

 Pantoprazole is gastric acid pump inhibitor and antiulcer agent. It is a 
  specific inhibitor of the proton pump of H+/K+ ATPase, the enzyme 
  responsible for the secretion of acid by the gastric partial cells. By 
  virtue of its mechanism of action on the terminal phase of secretion. 
  Pantoprazole provokes  a durable inhibition of basal & stimulated 
  gastric acid secretion.
- Pantoprazole is rapidly absorbed , oral bioavailability is 77%. It is 
  highly bound to plasma proteins (98%) and undergoes extensive 
  hepatic metabolism by CYP2C19 & excreted mainly renally.
- Pantoprazole absorption is not affected by concomitant administration 
  of antacids & administration of Pantoprazole with food may delay its 
  absorption up to 2 hours or longer, but C max & extent of Pantoprazole 
  absorption are not affected

 Each enteric coated  tablet of Pantrol®  40 contain:
  Pantoprazole sodium sesquihydrate        40 mg.
- Each enteric coated  tablet of Pantrol® 20 contain:
  Pantoprazole sodium sesquihydrate        20 mg

Hypersensitivity to Pantrol®  product.

 Pantrol® may reduce the absorption of drugs whose bioavailability is 
  pH–dependent e.g( Ketoconazole, Itraconazole and other Azole 
  antifungals, Ampicillin, Esters, and Iron salts).
- Interaction of Pantrol® with other drugs which are  metabolized by 
  cytochrome P450 enzyme system cannot be excluded noteworthy plasma 
  concentration, of digoxin possibly increased.
- No clinical significant interactions were observed, studies have been 
  carried out on Carbamazepine, Caffeine, Diazepam, 
  Diclofenac, Ethanol, Glibenclamide, Metoprolol, Nifiedipine, Phynetoin,
  Theophylline, Warfarin and oral contraceptives. 
- No clinically relevant interactions were observed with concomitantly 
  administered antacids, Clarithromycin, Metronidazole and Amoxicillin. 

Pantrol® should be used with caution in pregnancy and breastfeeding 
 and should only be used when the potential benefits outweighs risks.

- Gastrointestinal tract disturbances including; nausea, vomiting, 
  abdominal pain, flatulence, diarrhea or constipation, and dizziness
- Rarely, dry mouth ,insomnia, drowsiness, malaise, blurred vision.
- Very rarely :taste disturbances, liver dysfunction,  hypersensitive 
  reactions including, urticaria,peripheral edema, angioedema, 
  bronchospasm, sweating, anaphylaxis, fever, photosensitivity, 
  depression, intestinal nephritis, blood disorders, arthralgia, myalgia and 
  skin reactions.
- May increase the risk of gastro-intestinal tract infections.
- Also reported raised triglycerides in some case.
Over dose:-
- If  you have taken too little Pantrol® or have forgotten to take it, don’t 
  take the dose late, but continue with the next regular dose on your dosing 
  schedule .
-Talk to your doctor if  you want to interrupt or prematurely discontinue 
  treatment with Pantrol®. 
-There are no known symptoms of overdosing  in human, in any case, the 
  doctor must be consulted.

Pantrol® should be used with caution  in patient  with  severe  liver  
  impairment. The dose has to be reduced  to 1 tablet (40 mg)  every 48 
  hours. Also the liver enzymes should be monitored during therapy. In 
  case of a raise of the liver enzymes, Pantrol® should be discontinued .
- Before treatment, the presence of gastric or esophageal malignancy 
  should be excluded.
- There has no experience with treatment in children.
- There are no known effects on the ability to drive and use machines.

Pantrol® 40   :   Strips of 7 Tablets, pack of 2 strips .  
 Pantrol® 20   :   Strips of 10 Tablets, pack of 5 or10 strips.  
- Hospital packs of different sizes.

Store in a cool dry place below 30° C, protect form light.