PRONID S.R. 200

PRONID S.R. 200
29 May

PRONID S.R. 200

Analgesics, Antipyretics, Anti-Inflammatory drugs

- Ketoprofen, a propionic acid derivative  as NSAIDs.
- Ketoprofen as other NSAIDs, that main use as analgesic, 
  anti-inflammatory and antipyretic. It acts by its inhibitory action on
  cyclo-oxygenase, which are involved in the biosynthesis of
  prostaglandine and thromboxane from arachidonic acid .  
- Ketoprofen is readily absorbed from the GIT, peak plasma
  concentrations occur about 0.5 to 2 hours after dose. 
- Ketoprofen is 99%  bound to plasma proteins, and the elimination
  half life in plasma is about 1.5 to 4 hours. 
- Ketoprofen is present  in breast milk.   
- Ketoprofen is metabolised in the liver mainly by conjugation with glucuronicacid, and is excreted mainly in the urine.  

Indecation

PRONID®  is indicated for adults and children over 15 years for the
 following cases:-  
- Long-term treatment of certain chronic inflammatory rheumatism
  and certain  painful and disabling osteo-arthritis.  
- Short-term treatment during acute exacerbation of joint
  inflammation such as tendinitis, bursitis, acute shoulder pain,
  microcrystalline arthritis such as gout, osteo-arthritis, lumbago,
  radiculalgia such as sciatica, pains and odema of the locomotor 
  system due to trauma. 
- Post-operative pain, dysmenorrhoea and to reduce fever.

Dosage & Administration

- PRONID®   should be taken with a large glass of water, during
  meals.  
-In long-term symptomatic treatment:-
 One Capsule of pronid SR 200 Per day or 1- 3 film coated tablet of
 100 mg to be divided to 1 to 3 intakes per day.
-In short-term symptomatic treatment of acute exacerbation:
 300 mg / day, to be divided to 1 to 3 intakes per day.
- In painful condition including dysmenorrhoea:
   25 to 50 mg every 6 to 8 hours

- Each Capsule of  PRONID®   S.R 200 contains: 
      Ketoprofen                 200 mg
- Each film Coated Tablet  of  PRONID®   100 contains: 
      Ketoprofen                 100 mg

- Hypersensitivity for  ketoprofen.   
- Gastrointestinal hemorrhage, cerebrovascular hemorrhage or other  
   hemorrhage in progress.
-Serious liver, kidney or heart diseases.

-PRONID®  must not be used with other NSAIDs including aspirin at 
 high doses, oral anticoagulants, heparin at curative or at prophylactic  
 doses or in the elderly , lithium , methotrexate , platelet aggregation 
 inhibiting drugs , potassium salts, diuretics, inhibitors of angiotensin 
 converting enzyme ,inhibitor angiotensin II enzyme cyclosporin and  
 tacrolimus , trimethoprim, beta-blockers, introutrine, and pentoxifylline  

- During the first five months of pregnancy  PRONID®   prescribed
  only  by physician if necessary. 
- As of the 6th month of pregnancy, PRONID® must not be taken in
  any case since it has a serious effect on the child, and if PRONID® 
  have taken, physician should be informed .     
- PRONID®   is not recommended to be used during lactation 

 Gastrointestinal disorders:- Nausea, vomiting, diarrhea,
  constipation, stomach pain, gastrointestinal discomfort, gastritis,
  stomatitis and more rarely colitis.
- Skin allergies:- Eruption, rash, pruritus, urticaria or skin
  photosensitivity.
-Headache, dizziness, drowsiness, allopecia, tinnitus, blurred vision,
  thrombocytopenia, rare cases of leukopenia, possibility of
  agranulocytosis, hypertension and odema.

Caution is necessary when PRONID® is prescribed with the following cases:- 
-History of asthma associated with a chronic rhinitis, chronic sinusitis,  
 polyps in the nose or that resulted from other NSAIDs. 
-Coagulation disorders, during concomitant anticoagulant treatment or 
 platelet aggregation inhibiting drugs treatment specially in the elderly, or in weakness or low body weight patients. 
-History of GIT disorders (e.g.  previous gastric or duodenal ulcer, 
 ulcerative colitis, crohn’s disease) .  
-Heart, liver or kidney disease, treatment with diuretics or recent 
 surgery .
- History of skin reaction during exposure to sun or UV rays.
-Congenital galactosemia, glucose or galactose malabsorption or 
 lactose deficiency.
- During long-term treatment : monitoring of blood cell count, hepatic 
 (Transaminase serum level) and renal function is recommended . 
 Note :- Driving or using machines should be avoided as dizziness,  
 drowsiness, convulsions or visual disorders may be produced 

- PRONID®   S.R 200mg Capsules:
   (Blisters of 10 Capsules, pack of one blister)
- PRONID®   100 mg film coated tablet  
   (Blisters of 10 tablets, pack of two blisters).
- PRONID®   100 mg film coated tablet  
   (Blisters of 15 tablets, pack of two blist

- Store in a temperature not exceeding  25°C.