Triptol 600

Triptol 600
29 May

Triptol 600

Neurological & Psychiatric Drugs

- Oxcarbazepine is structurally a derivative of carbamazepine, adding an 
  extra oxygen atom to the benzylcarboxamide group. This difference 
  helps reduce the impact on the liver of metabolizing the drug, and also
  prevents the serious forms of anemia occasionally associated with 
  carbamazepine. Aside from this reduction in side effects, it is thought to 
  have the same mechanism as carbamazepine -sodium channel 
  inhibition- and is generally used to treat partial seizures in epileptic 
  children and adults.
- Oxcarbazepine  is the standard treatment for epilepsy.
- Oxcarbazepine works by keeping the brain’s “overexcitable” nerve cells 
  under control. This suppresses or reduces the frequency of such 
  seizures.

Indecation

- Triptol® is used to treat partial seizures with or without secondarily 
  generalized tonic-clonic seizures. 
- Triptol® can be used alone or in combination with other antiepileptic 
  medicine.
- Triptol® is used in Pediatrics: 
- Monotherapy in the treatment of partial seizures in children 4-6 years.
- Adjunctive therapy in the treatment of partial seizures in children 2-16     
  years.

Dosage & Administration

- Triptol® can be used either as a monotherapy or in combination with  
  other anti-epileptic drugs. In both monotherapy and combination
  therapy, Triptol® should be started with a clinically effective dose given 
  in two doses per day. The dose may be increased according to the 
  patient's clinical response. In the case of co-treatment, it may be 
  necessary to reduce the dosage of the other anti-epileptic or increase the
  dose of Triptol® more slowly.
- Triptol® can be taken with or without food. The oral suspension is 
  available for use in younger children who are unable to swallow tablets. 
  Before using a Triptol® suspension, the bottle should be carefully 
  cooled and the dose should be immediately withdrawn from the bottle. 
  The suspension can be swallowed directly from a dose-measuring 
  syringe or can be diluted in a small glass of water before directly 
  manipulating.
- When the oral suspension of Triptol® is prescribed, the dose should be 
  determined in milliliters. 
- In case of monotherapy or joint treatment in adults: The treatment can 
  be started with a daily dose of 600mg, divided into two doses. the daily
  dose can be increased at weekly intervals, in increments not exceeding 
  1200 mg. 
- Children: In monotherapy and joint therapy, starting dose therapy (8-10     
  mg / kg / day) is divided into two doses. The best results are usually with
  a dose of (30mg/kg/day). The maximum dose for child is 46mg/kg/day.
- If the clinical condition is called, the daily dose may be increased at weekly 
  intervals in increments not exceeding 10 mg / kg / day, up to a maximum
  dose of 60 mg / kg / day.
- Elderly patients: It is recommended to adjust the dose in elderly patients
  with renal impairment who may be at risk of low blood sodium.
- Patients with renal impairment: In patients with renal impairment (creatine 
  clearance less than 30 ml / min), treatment is started at the usual half-dose 
  (300mg / day) and the dose is increased at intervals of not less than one 
  week until the desired clinical response is achieved. They should be 
  monitored well during dose calibration.
- Your doctor may increase the dose gradually to find the best dose for you. 
- The best results are usually with doses between 600 and 2,400 mg per day.
If you forget to take Triptol:-
- If you have forgotten one dose, take it as soon as you remember. However, 
  if it is time for your next dose, do not take the missed dose. Go back to your
  regular dosing timetable. Do not take a double dose to make up for a 
  forgotten dose.
- Treatment may be needed for many years to control the seizures. Do not 
  change the dose or stop treatment without talking to your doctor.
 

- Each film coated tablet of Triptol® 600  contains:
   Oxcarbazepine                                 600 mg   
- Each film coated tablet of Triptol® 300 contains:
   Oxcarbazepine                                 300 mg
- Each 1 ml of Triptol® For oral suspension contains:
   Oxcarbazepine                                   60 mg   

- Triptol® should not be administered to patients who have shown hyperse-   
  nsitivity to Oxcarbazepine or any of the ingredients of the Triptol® or if 
  you are allergic to eslicarbazepine.

  Please tell your doctor or pharmacist if you are taking, have recently taken
  or might take any other medicines and this applies especially to:
- Hormonal contraceptives, such as oral contraceptives. 
- Other antiepileptic and enzyme inducing medicines, such as carbamaz-
  epine, phenobarbital, phenytoin or lamotrigine and rifampicin.
- Medicines that reduce the level of sodium in your blood, such as diuretics 
  (used to help the kidneys get rid of salt and water by increasing the amount 
  of urine produced), desmopressin and nonsteroidal anti-inflammatory 
  medicines, such as indometacin and ibuprofen.
- Lithium and monoamine oxidase inhibitors (medicines used to treat mood 
  swings and some types of depression).
- Medicines that control the body’s immune system, such as ciclosporin 
  and tacrolimus. 

- Contact your doctor if you become pregnant, think you may be pregnant or 
  are planning to become pregnant while taking Triptol®. It is important that 
  seizures during pregnancy are controlled but Triptol® may affect the 
  growth of your unborn baby. 
- Your doctor will discuss the benefits and possible risks of the use Triptol® 
  during pregnancy.
- Triptol® should not be used during breast feeding. 
Effects on ability to drive and use machines:-
- You should be aware that Oxcarbazepine can cause side effects like
   dizziness and drowsiness, blurred vision, double visions, lack of muscle 
   coordination or depressed level of consciousness, which can influence 
   your ability to drive or operate machines. Do not drive or operate 
   machines if you experience such side effects. 

- Very common: tiredness; headache; dizziness; drowsiness; feeling
  sick (nausea); being sick (vomiting); double vision.
- Common: weakness; memory disturbances; impaired concentration; 
  apathy; agitation; confusion; blurred vision; visual disturbance; 
  constipation; diarrhoea; stomach (abdominal) pain; acne; hair loss;  
  balance disturbances; weight increased.
Overdosage:-
- If you or anyone take too many Triptol®  you should contact you 
  doctor directly or go to the nearest hospital even if there are no signs 
  of discomfort. Symptoms of overdose are drowsiness, dizziness, 
  nausea, vomiting, an abnormal degree of muscular or bodily activity, 
  lack of co-ordination of movements and uncontrolled eye movements.
 

- Tell your doctor or pharmacist before takingTriptol®: if you have ever
  shown unusual sensitivity, if you have kidney disease, if you have
  serious liver disease, if you are taking diuretics, if you have heart 
  disease, shortness of breath and/or swelling of the feet or legs due to
  fluid build-up, if your blood level of sodium is low, if you are a woman
  taking a hormonal contraceptive.
- Tell your doctor if you develop any of the following symptoms after 
  talking Triptol® : if you experience an allergic reaction, if you notice 
  symptoms of hepatitis such as jaundice, if you notice possible 
  symptoms of blood disorders such as tiredness, being short of breath 
  when exercising, looking pale, headache, chills, dizziness, frequent 
  infections leading to fever, sore throat, mouth ulcers, bleeding or
  bruising more easily than normal, nose bleeds, reddish or purplish 
  patches, or unexplained blotches on the skin, if you have a fast or 
  unusually slow heart beat. 
- Triptol® can lower the sodium levels in your blood further which may
   lead to symptoms of sodium shortage, If you have a renal disease your   
  doctor may examine your blood before and at regular intervals after starting 
  
  treatment with Oxcarbazepine.  
- if you have heart problems such as heart failure, (breathlessness and
   swollen ankles). 
- if you have a heart rhythm disorder.
- if you are planning to become pregnant

- Triptol® 600 tablet : Blister of 10 tablets pack of 3 blisters.
- Triptol® 300 tablet : Blister of 10 tablets pack of 3 blisters.
- Triptol® suspension 60mg / 1 ml :Bottle of 100 ml

- Tablet : store in at temperature not exceed  25°C, a way from light. 
- Suspension : store in at temperature not exceed  25°C, a way from light.