In case of prolonged use or application on extensive area, the following interactions must be considered:
- Concurrent use of corticosteroids with potassiumdepleting diuretics may enhance hypokalemia; patient should have serum potassium level determinations at frequent intervals.
- Concurrent use of corticosteroids with cardiac glycosides (digoxin) may enhance the possibility of arrhythmia of digitalis toxicity.
- The ulcerogenic potential of NSAIDs may be increased when used concurrently with corticosteroids.
- Concurrent use of corticosteroids with hypoglycemics may increase blood glucose levels; dosage adjustment of the antidiabetic agent is needed.
- Corticosteroids may reduce serum salicylate levels by increasing metabolism and/or clearance. Concurrent use needs caution especially in hypoprothrombinemia.
- Although reports are conflicting, caution is recommended when corticosteroids are used together with anticoagulants especially in patients prone to gastrointestinal ulceration and hemorrhage.