Batrim Forte

Batrim Forte
26 May

Batrim Forte

Antibiotics & Antibacterial

- BATRIM® is a synthetic antibacterial combination product, it exerts its  action by sequential blockade of two bacterial enzyme systems in the 
  biosynthesis of folinic acid (Tetra hydro folic acid) which is necessary for  DNA synthesis in the micro-organisms. 
- BATRIM® is rapidly absorbed from the gastro-intestinal tract following  administration. 
- Peak blood levels for the individual components occur 1 to 4 hours after oral administration. 
- BATRIM® diffuses freely throughout the body tissues and fluids including: kidneys, liver, lung, saliva, bile, prostatic tissue and fluid, and vaginal secretions. It can crosses the placenta and detected in the breast 
  milk. 
- BATRIM® is metabolized in the liver and eliminated primarily by the kidneys. 

Indecation

  BATRIM® is used for the treatment of:
- Urogenital infections (caused by Escherichia coli, klebsiella species, 
   Enterobacter species) such as acute and chronic cystitis, urethritis, pyelonephritis and prostatitis. 
- Gastro-intestinal infections including: typhoid and paratyphoid fever, bacillary dysentery and cholera. 
- Respiratory tract infections: acute and chronic bronchitis, bronchiectasis  pneumonia (including pneumocystis carinii pneumonia), tonsillitis, pharyngitis and acute otitis media in pediatric patients caused by treptococcus pneumonia or haemophilus influenza. 
- Other uses included the treatment of biliary tract infections, brucellosis, Nocardiosis and skin and soft tissue infections such as acne. 

Dosage & Administration

 Adults and children over 12 years old :
- Usual dose : one tablet of BATRIM® forte or two tablets of BATRIM® 480 twice daily. 
- High dosage for severe infections: one tablet and half of BATRIM®forte or three tablets of  BATRIM®480 twice daily.
- Minimum dosage and dosage for long term treatment: one tablet  of BATRIM® 480 (or one half  tablet of  BATRIM® forte ) twice daily. 
- Uncomplicated gonorrhoea : 4 tablets of BATRIM® 480(or 2 tabletsBATRIM® forte )twice daily for two days, or 5 tablets of BATRIM® 480(or 2 tablets and half of  BATRIM® forte ) followed by a further dose of  5 tablets of BATRIM® 480(or 2 tablets and half of  BATRIM® forte )   8 hours later .If poor patient compliance is expected, single dose of 8 tablets of BATRIM®480 (or 4 tablets and half of  BATRIM® forte ) taken under supervision may be employed .
- oropharyngeal gonococcal infection :2 tablets of BATRIM® 480 (or 1  tablets  of BATRIM® forte ) three times daily for 7 days , or 9 tablets  of  BATRIM®480 (or 4 tablets and half of BATRIM® forte )daily for 5 days  .
 Children:
- 6 -12 years of age: one tablet of BATRIM® 480  twice daily or  2  teaspoonfuls (10ml) of BATRIM® oral suspension twice daily  
-1- 6 years: 1 teaspoonfuls (5 ml) of BATRIM® oral suspension twice daily.  
- Infants 2 -12 months:  1/ 2 teaspoonfuls (2.5 ml) of BATRIM® oral  suspension twice daily. 
-In the treatment of Pneumocystis carinii pneumonia : 120 mg /kg daily in 2  to 4 divided doses for 14 to 21 days in adults and children over 4 weeks of  age.
 -Norcardiosis: doses 2.88 g to 3.84g daily in  divided doses for up to 3 
 months have been used .        
- BATRIM®  is ideally taken after meals with plenty of water or fluid.

- Each tablet of  BATRIM®  forte  contains: 
   Sulphamethoxazole     800 mg 
   Trimethoprim                                 160 mg 
- Each tablet of  BATRIM®  480 contains: 
   Sulphamethoxazole     400 mg 
   Trimethoprim                                80 mg 
- Each 5 ml of BATRIM® Oral Suspension contains:
   Sulfamethoxazole    200 mg 
   Trimethoprim                                  40 mg 

BATRIM®  is contra-indicated in: 
- Patients with a known hypersensitivity to  the sulphonamides or   Trimethoprim. 
- Megaloblastic anemia due to folic acid deficiency. 
- Pediatric patients less than 2 months of age. 
- Severe renal insufficiency or hepatic damage. 
- Patients with serious hematological disorders or with glucose-6-phosphate dehydrogenase deficiency. 

- BATRIM® potentiate the effect of diuretics (thiazide) and oral  hypoglycemic agents. 
- BATRIM®  may enhance the effect of phenytoin. 
- BATRIM® may prolong the prothrombin time in patients who are receiving the anticoagulant (warfarin.)
-Since BATRIM® can reduce the effect of oral contraceptives, female patients should be asked to take additional contraceptives precautions during BATRIM® treatment.

BATRIM® should not be preferably used during pregnancy, especially in the third trimester, otherwise BATRIM® should be used concomitantly with folic acid.
- The administration of  BATRIM®  to lactating women represents negligible risk to the sucking infant 

 BATRIM®is well tolerated at the recommended doses so any side effects that may occur are mild, these   include: 
- Gastro-intestinal disturbances such as: nausea, vomiting, anorexia. 
- Allergic skin reactions. 
- Hematological changes may be observed in some patients, particularly in elderly.
- chronic dosage can cause bone marrow depression. 

Over dosage: 
-Nausea, vomiting, headach, dizziness.

-BATRIM® should be given with caution to: 
   - Elderly patients. 
   - Patients with impaired renal or hepatic function. 
   - Patients with severe allergic or bronchial asthma. 
- BATRIM®should be discontinued if skin rash appears. 
-Urine analysis and renal function tests should be performed during long term therapy. 

BATRIM® forte tablet 
- Blister of 10 Tablets, Pack of  10 blisters
 BATRIM®tablet 480 mg 
- Blister of 10 Tablets, Pack of  2 blisters
- Blister of 10 Tablets, Pack of  10 blisters
- Hospital packs with different sizes.  
 BATRIM® oral suspension  
- Bottle of 100 ml.
- Bottle of 60 ml.

 Store in a dry place at a temperature not exceeding 25oC  .