Dentazol

Dentazol
17 May

Dentazol

Antibiotics & Antibacterial

- Spiramycin  is a macrolide bacteriostatic antibiotic with an 
  antimicrobial spectrum similar to that of Erythromycin and 
  Clindamycin.    
- Metronidazole, a 5-nitroimidazole derivative, is active against 
  various anaerobic bacteria and protozoa .  
- The complementary combination of Spiramycin and 
  Metronidazole shows synergism in inhibiting certain sensitive 
  bacteria involved in buccodental infections. 
- Spiramycin is incompletely absorbed from gastrointestinal tract 
  and is widely distributed in the tissues. It has a half- life of about 
  8 hours. Spiramycin is metabolised in the liver to active 
  metabolites; substantial amount are excreted in the bile and about 
  10% in the urine. It is distributed in to breast milk.        
- Metronidazole is readily absorbed after oral administration and 
  bioavailability approaches 100%. Metronidazole has a large 
  volume of distribution in the body. It  crosses the placenta. 
- Metronidazole is metabolized in the liver and It’s elimination half 
  life is about 8 hours. The majority of a dose of Metronidazole is 
  excreted in the urine mainly as metabolites; a small amount 
  appears in the faeces.

Indecation

DENTAZOL® is highly effective in the treatment of acute, 
  chronic and relapsing  stomatologic infections such as :
- Buccodental infections due to aerobic and anaerobic germs 
  sensitive to Spiramycin and Metronidazole. 
- Dental infections as in dental abscesses, stomatitis, aphthous ulcer,
  perimaxillar cellulites, pericoronitis, periodonitis and periodontal
  infection. 
- Parotiditis and submaxillaritis.
- Pre and post-operative prophylaxis in odontostomatologic surgery.  
- Tonsilitis and gingivitis .
- DENTAZOL® can be efficacious in the treatment of those 
  patients with AIDS and diarrhea in which cryptospordium is 
  identified.  

Dosage & Administration

DENTAZOL® is recommended to be used during meals.

Children:
 6 -10 years : 1 tablet of DENTAZOL® 2 times daily.
 10 -15 years : 1 tablet of of DENTAZOL® 3 times daily.

Adults:
 2  tablets of DENTAZOL® 2- 3 times daily.  Or one tablet of DENTAZOL® Forte 2 -3 times daily.

- Each film coated  tablet of DENTAZOL® Forte contains: 
   Spiramycin                     1500000 IU
   Metronidazole                250 mg 
- Each film coated  tablet of DENTAZOL® contains:
   Spiramycin                     750000 IU
   Metronidazole                125 mg 

- Hypersensitivity to Spiramycin and/or Metronidazole.
- Concomitant use of Ergotamine or other vasoconstrictor derivatives 
  of ergot.  
- Concomitant use of Disulfiram.

- Spiramycin Inhibit the absorption of Carbidopa accompanied by
  decrease in plasma levels of levodopa, hence, the dose adaptation 
  and clinical monitoring of levodopa is recommended.  
- Drugs that may affect Metronidazole include Barbiturates and 
  Cimetidine.  
- Drugs that may be affected by Metronidazole include 
  Anticoagulants, Disulfiram, Hydantoins and Lithium.  
- Spiramycin may increase serum Theophylline concentration.   
- Spiramycin can increase the effects of oral Anticoagulants and 
  Digoxin.

- DENTAZOL® should not be used in the first trimester of 
  pregnancy . 
- Lactating women who must use DENTAZOL® should stop 
  lactation during treatment period. 

DENTAZOL® Forte tablets are well tolerated. The most common 
  side effects are:  
- Mild gastrointestinal disturbances as nausea, vomiting, diarrhea, 
  unpleasant taste and darkening of urine may occur.
- Rare case of rash, vertigo, ataxia and leukopoenia. 

- The treatment should be discontinued in case of ataxia and vertigo. 
- Alcoholic drinks should be avoided during treatment. 
- DENTAZOL® should be used with great care in patients with 
  blood dyscrasias or with active diseases of the central nervous 
  system. 
- DENTAZOL® should be used cautiously in patients with hepatic 
  dysfunction.
- The dosage of oral –anticoagulants( e.g. warfarin) should be  
  adapted when associated with DENTAZOL®.

- DENTAZOL® Forte:- Blister of 10 tablets, Pack of 1 blisters or 
  two blister.
- DENTAZOL®:- Blister of 10 tablets, Pack  of 1 or 2 blister.
- Hospital packs of different sizes.

-Store in a dry place at a temperature below 30oC.