Erothin 200

Erothin 200
17 May

Erothin 200

Antibiotics & Antibacterial

- Erythromycin is a macrolide antibiotic with a broad bacteriostatic
  action against many Gram-positive and to a lesser extent some
  Gram-negative bacteria, as well as other organisms including 
  Mycoplasmas, Spirochaetes, Chlamydias, Rickettsias Actinomyces
  and some Opportunistic Mycobacteria .  
- Orally administered Erythromycin Ethylsuccinate suspension is 
  readily and reliably absorbed under both fasting and non fasting
  conditions.
- The stearate salt for Erythromycin is poorly soluble in water, food
  may reduce the absorption of the stearate,  although this depends to
  some extent on the formulation so the optimal blood level are
  achieved when it’s taken on an empty stomach.  
- The peak plasma concentrations generally occur between 1 -4 hours
  after administration, and  have been  reported to range between
  about 0.3 - 0.5µg /ml after administration of 250mg  of 
  Erythromycin base, and about 0.3 - 1.9 µg/ml after administration 
  of 500mg .
- The half life of  Erythromycin is usually reported to be roughly in
  the  range 1.5 - 2.5 hours .
- Erythromycin diffuses readily into most body fluids. 
- In the presence of normal hepatic function Erythromycin
  concentration is increased  in the liver and excreted in the bile. 
- Erythromycin crosses the placental barrier and excreted in breast
  milk. 

Indecation

- EROTHIN® is used in the treatment of a wide variety of infections    
  caused by susceptible organisms, its uses have included: bronchitis, 
  severe campylobacter enteritis, chancroid, diphtheria, legionnaire’s  
  disease and other Legionella infections,  neonatal conjunctivitis, 
  pertussis, pneumonia, sinusitis and trench fever. 
- Combined with Neomycin, for the prophylaxis of surgical infection 
  in patients undergoing bowel surgery. 
- EROTHIN® is used as an alternative to penicillin in penicillin-  
  allergic patients with various conditions.

Dosage & Administration

Adults:
- The usual dose 1 to 2 g daily in 2 to 4 divided doses.
-  For severe infections this may be increased to up to 4g daily in  
   divided doses.
- A maximum of 1.5g daily has been suggested for patients with
  severe renal impairment.
Children :
- The usual dose about 30 to 50 mg/kg of body weight daily in divided
  doses although it may be doubled in severe infections.
- A recommended dose for children aged 2- 8 years is l g daily in 
  divided doses. 
- Infants and children up to 2 years of age, 500mg daily in divided
  doses.  
- Or as directed by the physician.

- Each Film Coated Tablet of  EROTHIN® 500 mg  contains: 
   Erythromycin 500mg (as Erythromycin Stearate USP)
- Each Film Coated Tablet of  EROTHIN® 250 mg  contains: 
   Erythromycin 250mg (as Erythromycin Stearate USP)
- Each 5 ml of EROTHIN® 200 mg  for oral suspension contains: 
   Erythromycin 200mg (as Erythromycin Ethylsuccinate USP) 
- Each 5 ml of EROTHIN® 125 mg for oral suspension contains: 
   Erythromycin 125mg (as Erythromycin Ethylsuccinate USP)

- EROTHIN® is contraindicated in patients with known
  hypersensitivity to this antibiotic. 
- EROTHIN® is contraindicated in patients taking Terfenadine,
  Astemizole or Cisapride.  

- EROTHIN® used in patients who are receiving high doses of 
  Theophylline may be associated with an increase in serum
  Theophylline levels and potentiate Theophylline toxicity. 
- Concomitant administration of EROTHIN® and Digoxin has been
  reported to result in elevated Digoxin serum levels. 
- There have been reports of increased anticoagulant effects when 
  EROTHIN® and Oral anticoagulants were used concomitantly. 
- Serum concentrations of drugs metabolized by the Cytochrome P450
  system should be monitored closely in patients concurrently receiving
  EROTHIN® .

 Administer under medical supervision.  

- The most frequent side effects are gastrointestinal disturbances and are
  dose-related they include nausea, vomiting, abdominal pain, diarrhea 
  and anorexia .

- Caution should be exercised when EROTHIN® is administered to
  patients with impaired hepatic function. 
- Prolonged or repeated use of  EROTHIN® may result in an
  overgrowth of non susceptible bacteria or fungi. If superinfection
  occurs, EROTHIN® should be discontinued and appropriate therapy
  instituted. 
- Abnormal liver function test results may occur.

-EROTHIN® Film Coated Tablets 500mg &250 mg .
  (Blisters  of 10 Tablets, Pack of 2 Blisters )  .
- EROTHIN® Oral suspension 200mg &125 mg .
  (Bottles  of  100 ml after reconstitution) .
- Hospital packs of different sizes .

-Store the drug tightly closed in a dry place at a temperature below
  25oC.
- After reconstitution, store in a refrigerator and use within one week  .