OFLOXIN 200

OFLOXIN 200
17 May

OFLOXIN 200

Antibiotics & Antibacterial

- Ofloxacin is a fluoroquinolone, synthetic broad spectrum 
   antimicrobial agent for oral administration. 
- Ofloxacin is rapidly well absorbed from the gastro-intestinal 
  tract. Oral bioavailability is almost 100% and a peak plasma 
  concentration of 3 to 5 μg/ml is achieved 1 to 2 hours after a dose 
  of 400 mg by mouth. 
- Absorption may be delayed by the presence of food, but the 
  extent of absorption is not substantially affected. The plasma 
  half-life ranges from 4 to7 hours.
- Ofloxacin is widely distributed in body fluids, including the 
  CSF, It crosses the placenta and distributed into breast milk. It  
  also appears in the bile. 
- Ofloxacin has a  limited metabolism to desmethyl and N-oxide 
  metabolites, desmethylofloxacin has moderate antibacterial 
  activity. 
- Ofloxacin is eliminated mainly by the kidneys and 65 to 80% 
  of a dose is excreted unchanged in the urine, over 24 to 48 hours. 

Indecation

 OFLOXIN® is used in the treatment of a wide  range of    
  infections including: 
- Biliary tract infections. 
- Bones and joint infections. 
- Gastro-enteritis (including diarrhoea and campylobacter enteritis, 
  cholera, shigellosis and salmonella enteritis.)
- Meningitis, otitis media and Q-fever.
- Lower respiratory tract infections. 
- Skin infections, septicemia and leprosy. 
- Typhoid and paratyphoid fever. 
- Urinary tract infections and exacerbation of cystic fibrosis

Dosage & Administration

 The usual adult oral dose of OFLOXIN® ranges from 200 mg 
  to 400 mg twice daily depending on the severity and the nature 
  of the infection. 
- Oral doses of OFLOXIN® up to 400 mg may be given as a 
   single dose, preferably in the morning. 
- OFLOXIN® must be taken on the empty stomach at least 
  1 hour before or 2 hours after meals with a full glass of water.

* Each film-coated tablet of  OFLOXIN® 400 contains:
   Ofloxacin USP    400 mg  
* Each film-coated tablet of  OFLOXIN® 200 contains: 
   Ofloxacin USP    200 mg 

 OFLOXIN® is contraindicated in patients with a history of
   hypersensitivity to Ofloxacin or other quinolone derivatives. 
- Epileptics and patients with pre-existing CNS lesions. 
- Children, adolescent, pregnant or breast-feeding mothers

- Fluoroquinolones are known to inhibit hepatic drug metabolism 
   and may interfere with the clearance of drugs metabolized by the 
   liver such as theophylline.
- On the other hand, Cations like aluminium, magnesium, or iron 
   reduce the absorption of ofloxacin and related drugs when given 
   concomitantly. 

 OFLOXIN® should be used during pregnancy only if clearly 
   needed. 
- OFLOXIN® should be used with caution in lactating mothers. 

- As with other quinolones, side effects are usually:
- Gastrointestinal disturbances including: nausea, vomiting, 
  diarrhoea, abdominal pain and dyspepsia. 
- Headache, dizziness and restlessness are among the commonest 
  effects on the CNS. 
- Hypersensitivity type reactions affecting the skin, in addition to 
  rash and pruritus.   

- OFLOXIN® should be used with caution in psychiatric disorders, 
  renal and hepatic impairment, glucose-6-phosphate dehydrogenase 
  deficiency and diabetes.
- During treatment, patients should not expose themselves to  
  sunlight, UV rays or sunray lamp (due to photosensitivity  
  reactions.) 
- Avoid driving or other activities requiring alertness. 
- Antacid or iron should not be taken within 2 hours of taking     
  OFLOXIN®.   

 OFLOXIN® tablet 400 mg (Blisters of 10 Tablets, Pack of one 
   blister)
- OFLOXIN®  tablet 200 mg (Blisters of 10 Tablets, Pack of one 
   blister) 
- Hospital packs of different sizes

 Store in a dry place at a temperature  not exceeding 25oC.