SPIRAMED

Spiramycin is a macrolide antimicrobial agent. It acts by 
 binding reversibly to the 50S subunit of ribosome's, resulting 
 in blockage of the transpeptidation reaction ,inhibition of 
 protein synthesis and hence inhibition of cell growth .
- Its action is primarily bacteriostatic but high concentrations 
 are slowly bactericidal against the more sensitive strains .
- Spiramycin is active against many Gram - positive bacteria
 including:- streptococcus pyogenes, streptococcus viridians
 corynebacterium diphtheriae and staphylococcus aureus , and  
 to a lesser extent some Gram - negative bacteria such as  
 Neisseria meningitis , Bordetella pertussis , campylobacter 
 clostridium and about 50% of Haemophilus influenza.
- Spiramycin is incompletely absorbed from the GIT and the
 administration with Food reduces bioavailability by 50% and  
 by delays time to peak serum concentration so that it should 
 given on an  empty stomach
- Spiramycin is widely distributed in the tissues but it dose not
 diffuse into CSF to an appreciable and it is distributed into  
 breast milk.
- Spiramycin is metabolized in the liver to active metabolites;
 substantial amount are excreted into bile and about 10% in the  
 urine.