Zinaxil 500
-Cefuroxime axetil is an oral prodrug of the bactericidal cephalosporin antibiotic, Cefuroxime, which is active against a wide range of
Gram-positive and Gram-negative organisms.
-Cefuroxime is resistant to most beta-lactamases and consequently, is active
against many Ampicillin-resistant strains and Amoxicillin-resistant strains.
The bactericidal action of Cefuroxime results from inhibition of cell-wall
synthesis by binding to essential target proteins.
-Cefuroxime axetil is absorbed from the gastro-intestinal tract and is rapidly
hydrolysed in the intestinal mucosa and blood to Cefuroxime. The
absorption of Cefuroxime axetil is enhanced in the presence of food .
-Peak plasma level of Cefuroxime in plasma occur approximately 2 to 3
hours after oral administration .The plasma half life is about 1.2 hours .
Plasma levels of Cefuroxime is reduced by dialysis .
-Cefuroxime bound to plasma protein by 50% .
-Cefuroxime is widely distributed in the body. It crosses the placenta and
has been detected in breast milk.
- Cefuroxime is not metabolised and is excreted unchanged in the urine.
Small amounts of Cefuroxime are excreted in bile.