CYCLOFEN
-Paracetamol is a para-aminophenol derivative salicylate, it is
a non-Opioid . It has analgesic, antipyretic properties and
weak anti-inflammatory Activity.
-Paracetamol produces central and peripheral analgesia by
elevation of the pain threshold and inhibition of prostaglandin
biosynthesis, and antipyretic action through the effect on the
hypothalamic heat-regulating center, resulting in peripheral
vasodilatation, increased blood flow through the skin,
sweating and heat loss.
-Paracetamol is readily absorbed from the gastro-intestinal
tract with peak plasma concentertion occurring about 10 to 60
minutes after oral administration.
-Paracetamol is distributed into most body tissues. It crosses
the placenta and it presents in breast milk.
-Paracetamol is metabolised predominantly in the liver and
excreted in the urine mainly as the glucuronide and sulphate
conjugates. Less than 5% is excreted as unchanged
Paracetamol.
-The elemination half-life of Paracetamol varies from about
1 to 3 hours.
-Caffeine is absorbed readily after oral dose and is widely
distributed in the body. It is also absorbed through the skin.
-Caffeine passes readily in to the CNS. Low concentrations are
also present in breast milk.
-Caffeine is metabolised almost Completely in the liver and
excreted in urine.
-The elimination half- life of Caffeine are about 3 to 7 hours.
-Pyrilamine is a first generation antihistamine targeting the H1
receptor however, it rapidly permeates the brain often causing
drowsiness ,these agents also have varying degrees of
anticholinergic and CNS activity (sedation).
-It is used in over-the-counter combination products to treat
the common cold and menstrual symptoms.