Domolin 10
-Domperidone is dopamine antagonist, which selectively blocks
peripheral dopamine receptors both in the gastrointestinal wall
and in the chemoreceptor trigger zone which lies outside the
blood brain barrier in the area postrema.
- Domperidone has antiemetic properties similarl to those at
metoclopramide and certain neuroleptic drugs.
- Unlike metoclopramide and certain neuroleptic drugs, Domperidone
does not cross the blood brain barrier and hence significantly
lacks the extrapyramidal side effects associated with these drugs.
- Domperidone is rapidly absorbed after oral
administration, with peak plasma concentration at
approximately 30 minutes.
- The low absolute bioavailability of oral dose
approximately 15% is due to an extensive first pass
metabolism in the gut wall and liver.
- More than 90% of Domperidone is bound to plasma
proteins, and has a terminal half-life of about 7.5 hours,
but it is prolonged in patients with severe renal impairment.