OFLOXIN 400
- Ofloxacin is a fluoroquinolone, synthetic broad spectrum
antimicrobial agent for oral administration.
- Ofloxacin is rapidly well absorbed from the gastro-intestinal
tract. Oral bioavailability is almost 100% and a peak plasma
concentration of 3 to 5 μg/ml is achieved 1 to 2 hours after a dose
of 400 mg by mouth.
- Absorption may be delayed by the presence of food, but the
extent of absorption is not substantially affected. The plasma
half-life ranges from 4 to7 hours.
- Ofloxacin is widely distributed in body fluids, including the
CSF, It crosses the placenta and distributed into breast milk. It
also appears in the bile.
- Ofloxacin has a limited metabolism to desmethyl and N-oxide
metabolites, desmethylofloxacin has moderate antibacterial
activity.
- Ofloxacin is eliminated mainly by the kidneys and 65 to 80%
of a dose is excreted unchanged in the urine, over 24 to 48 hours.