Paradol® Cold & Flu  is contraindicated in the following cases: 
- Hypersensitivity to any of the ingredients. 
- Should not  be used by patients taking monoamine oxidase inhibitors,  
  antidepressants or within two weeks of stopping such treatment.
- Hepatic or renal dysfunction.

on prothrombin time.
 The liver effects of Paradol® Cold & Flu  may be increased by the use of 
 alcohol and the concomitant use of certain drugs which enhance the 
 metabolism of Paracetamol in the liver (i.e. barbiturates, tricyclic 
 antidepressants).
 Coadministration of Pseudoephedrine and MAOIs may lead to hypertensive 
 crisis. This effect may persist for up to 2 weeks after discontinuation of 
 MAOIs.
 Enhanced sedative effects of Chlorpheniramine can occur with simultaneous 
 administration of alcohol, anxiolytics and hypnotics. Tricyclic 
 antidepressants and antimuscarinics can increase antimuscarinic side effects.

 -As with any drug medical advice should be taken before using Paradol® 
  Cold & Flu
- Paradol® Cold & Flu  should not be used during breast feeding as there  
  may be risks associated with use of antihistamines in infants. 

 Paracetamol when taken in recommended doses, is usually free from side  
  effects. However, skin reactions such as urticaria have been reported 
  rarely. 
-Pseudoephedrine HCl may occasionally cause anxiety, tremor,dizziness, or 
 cardiovascular effects including tachycardia , hypertension, insomnia and 
 urinary retention.  
- Chlorpheniramine the antihistamine, may cause sedation, gastrointestinal 
 disturbances, and antimuscarinic effects. 
Overdose:-
- Paracetamol over dose may cause liver damage. Early symptoms may 
 include( pallor, nausea, vomiting, diaphoresis and general malaise).
 Overdose should be promptly treated by gastric lavage followed by  
 intravenous N-acetylcysteine or methionine.
- Pseudoephedrine overdose is likely to result in effects similar to those  listed as adverse effects, and may also produce excess sympathetic  
 stimulation.7- 8 caplets has been shown to cause hypertension in 
 normotensive subject.
- Treatment of Pseudoephedrine overdose is mainly symptomatic. Support 
 respiration and control hypertension. Convulsions should be supported  
 with an anticonvulsant if required. Elimination of Pseudoephedrine
 can be accelerated by acidification of the urine.
- Antihistamine overdose may cause sedation and central nervous system  
 depression.

Paradol® Cold & Flu  should be administered with caution in patients 
  with:-  
 -Sever hypertension, cardiac or peripheral vascular disease .
- Hyperthyrodism, diabetes mellitus or epilepsy.
- Breathing problem such as emphysema or chronic bronchitis, glaucoma or 
  difficulty in urination due to enlargement of the prostate gland.
- Do not take this product over 10 days or for fever more than 3 days unless  
  directed by a doctor.
- Do not  take other medication contining Paracetamol, nasal decongestants 
  or antihistamines at the same times, with
  Paradol® Cold & Flu . 
- Caution is also indicated when driving or operating machinery because the 
  drug contain an antihistamine with sedation effects .

- Paradol® Cold & Flu  oral solution:  (Bottle of 100 ml solution)
- Hospital of different sizes.
 

-Store in a dry place, at a temperature below  30 °C.