Senazol

Senazol
17 May

Senazol

Amoebicidal & Antiprotozoals

 Secnidazole is 5-nitroimidazole derivative, it has activity against 
 anaerobic bacteria and protozoa with properties similar to those of 
 metronidazole .
-Secnidazole enters micro–organisms by passive diffusion and 
 undergo activation by reduction of 5-nitro group .In anaerobic 
 micro –organisms such as Trichomonas, Giardia and  Entamoeba 
 spp, this intracellular reduction occurs via the pyruvateferredoxin 
 oxidoreductase complex  and result  in concentration gradient 
 across the cell membrane which , in turn, enhance transport of the 
 parent drug into the cell. The electron affinity of the  Secnidazole is 
 greater than that of  reduced  ferredoxin hence the drug interrupt the 
 normal electron flow.
- The mean absolute bioavailability of Secnidazole  is 100% (+26%) 
 after oral administration of single doses of 0.5 to 2g  and the 
 maximum plasma concentration occurs within3 hours.
- Secnidazole is rapidly, but not extensively, distributed in the body 
 after oral administration .
-Secnidazole crosses the placenta and can found in brest milk .
- The principle metabolite of Secnidazole RP 35843, is thought to 
 result from oxidation,persumably in the liver. No biological activity 
 has been reported for the metaboilte,
- Secnidazole does  not appear to cause induction or inhibiton of 
 hepatic cytochrome P450 isoenzyme .
- The plasma elemination half life is about 25 hours.
- Secnidazole is mainly eleminated in urine (50% of the  ingested 
 dose is excreted with 25 hours) . 

Indecation

 SENAZOL®  is indicated for the treatment of  :
- Intestinal amebiasis infections .
- Hepatic amebiasis infections.
- Giardiasis infections .
- Urogenital trichomoniasis in both males and females. 
- Anaerobic septicaemias.
- Non specific Vaginitis .

Dosage & Administration

SENAZOL® is recommended to be taken at the beginning 
 of meal. 
- Intestinal amebiasis
 Acute symptomatic amebiasis ( histolytic form ) 
 Adult :    2gm as a single dose .
Children : 30 mg/kg/day as a single dose.
 The dose is  to be taken for only one day .
 Asymptomatic amebiasis ( minute and cystic form  )
 The above dose dialy for 3 days     
- Hepatic amebiasis . 
 Adult : 1.5 gm per day as  a single or divided doses for 5 days


Children: 30 mg/kg/day as a single or divided doses for 5 days.
*During the sever stage of hepatic amebiasis , any pus or abscess should be drained in conjunction with SENAZOL®  treatment
-Trichomoniasis,Giardiasis and Bacterial Vaginosis .
 Adult    :       2 gm as  a single dose .
 Children:   30-40 mg/kg/ day as a single dose .
 Note:   Dose should be repeated another time if necessary .
 

 Each film-coated tablet of  SENAZOL®  1000  contains:
           Secnidazole            1000 mg              
- Each film-coated tablet of  SENAZOL®   500   contains:
           Secnidazole             500 mg
- Each 10 ml of  SENAZOL®   500 for oral susp. contains: 
           Secnidazole            500 mg              
 

 Hypersensitivity to the derivatives of Imidazole.
- Patient who suffer from organic neurological disorders and blood  
 dyscrasis.
 

 SENAZOL® potentiate the effect of Warfarin .Hence Prothrombin 
 levels should be checked frequently and eight days after drug 
 discontinuation .The dosage of oral anti- coagulant should be adjusted 
 during treatment with SENAZOL®. 
- Concomitant administration of Disulfiram with SENAZOL® may 
 cause delirium and confusion.

 It is not recommended to use during the first trimester of pregnancy or 
 during Lactation  .

- Gastrointestinal tract: Nausea, Vomiting, Anorexia, Diarrhea and 
 Sense of metallic taste.
- Hypersensitivity reactions: Rarely occur but sever : Urticaria and 
 Odema .
-Blood reactions : Moderate leukopenia, which disappears after 
 treatment discontinuation.
- Neurological disorders: Rarely , Dizziness, Ataxia, Paraesthesia, 
 Incoordination, Sensory and Motor polyneuritis. 
- Headache ,Tiredness, Furred tongue and Darkening of the urine 

 Avoid alcohol drinking during treatment with SENAZOL® because 
 of the possibility of the risk of abdominal cramps, flushing and 
 vomiting .
- If various neurological sings develop while using the drug  
 disconuation must be done immediately .
- Doses should be reduced in patient with sever liver disease .
- Blood test should be carried out before and after therapy in patient 
 suffering from leukopenia .


- SENAZOL® 1000 film-coated  tablets. 
(Blisters of 2 tablets, packs of one  blister).
-  SENAZOL®   500 film-coated  tablets. 
                     (Blisters of 4 tablets, packs of one blister).
-  SENAZOL® Oral susp.
                     (Bottles of 10 ml) .
- Hospital packs of different sizes.

Store in a dry place at a temperature below 30oC.