Trazol Plus
- TRAZOL® Plus : is a combination of Diloxanide furoate;
a luminal amoebicide and Metronidazole; a potent tissue
amoebicide. They have a synergistic and comprehensive
activity against all kinds of amoebiasis either vegetative or
cystic, and both intestinal or extra-intestinal amoebiasis
without need for addition drug.
-Metronidazole is a 5-nitroimidazole derivative with activity
against obligate anaerobic microorganism, both bacteria and
protozoa.
-Metronidazole is widely distributed, it appears in most body
tissues and fluids including bile, bone, breast milk, cerebral
abscesses, CSF, liver and liver abscesses, saliva, seminal
fluids and vaginal secretions and achieves concentration
similar to those in plasma.
-The mechanism of action of metronidazole is thought to
involve interference with DNA by a metabolite in which the
nitro group of Metronidazole has been reduced.
- Because of rapid absorption of Metronidazole, it is probably
less effective against parasites in the bowel lumen therefore it
is used in conjunction with a luminal amobicide diloxanide
furoate in the treatment of invasive amobiasis.
- Diloxanide furoate is a dichloroacetamide derivate, it is
a luminal amobicide acting principally in bowel lumen.
- Diloxanide furoate is suitable for eradication of the parasites
in amoeba and giardia cyst passers.